C1q-A Antibody (7H8): sc-58920

C1q-A Antibody (7H8) is a rat monoclonal IgG1 antibody that detects C1q-A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). C1q-A (7H8) antibody is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). C1q-A protein is a crucial component of the classical complement pathway, consisting of nine subunits that facilitate classical complement activation, thereby playing a vital role in the immune response. Notably, C1q-A is one of the three subunits, alongside C1q-B and C1q-C, that form disulfide-linked dimers of chain C, which are essential for structural integrity and function. The ability of C1q to interact with specific receptors on effector cells modulates activity, influencing both antibody-dependent and independent immune responses. Macrophages serve as the primary source of C1q, and expression is differentially regulated by anti-inflammatory drugs and cytokines, highlighting importance in maintaining immune homeostasis. Furthermore, C1q′s role in modulating the interaction of platelets with collagen and immune complexes suggests involvement in thrombotic complications arising from immune injuries. Deficiencies in C1q-A, C1q-B, and C1q-C can lead to the inactivation of the classical pathway, resulting in a rare genetic disorder characterized by lupus-like symptoms, underscoring the significance of C1q-A in both immune function and disease pathology.

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C1q-A Antibody (7H8) References:

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