Molecular structure of C-PAF (Carbamyl-PAF ), CAS Number: 91575-58-5
C-PAF (Carbamyl-PAF ) (CAS 91575-58-5)
See product citations (3)
Alternate Names:
mcPlatelet activating factor
Application:
C-PAF (Carbamyl-PAF ) is a PAF-R activator
CAS Number:
91575-58-5
Purity:
98%
Molecular Weight:
538.7
Molecular Formula:
C26H55N2O7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C-PAF (Carbamyl-PAF) is utilized as a non-hydrolyzable bioactive analog of PAF. As an activator of PAF-R, it binds stereospecifically to high and low affinity PAF-R and activates platelet aggregation. C-PAF (Carbamyl-PAF) is a useful tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. It stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase..
C-PAF (Carbamyl-PAF ) (CAS 91575-58-5) References
- Neuronal migration disorder in Zellweger mice is secondary to glutamate receptor dysfunction. | Gressens, P., et al. 2000. Ann Neurol. 48: 336-43. PMID: 10976640
- Platelet-activating factor (PAF) enhances apoptosis induced by ultraviolet radiation in corneal epithelial cells through cytochrome c-caspase activation. | Ma, X. and Bazan, HE. 2001. Curr Eye Res. 23: 326-35. PMID: 11910521
- Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | Barbuti, A., et al. 2002. Am J Physiol Heart Circ Physiol. 282: H2024-30. PMID: 12003807
- Antagonists of the Platelet-activating Factor Receptor Block Long-term Potentiation in Hippocampal Slices. | Arai, A. and Lynch, G. 1992. Eur J Neurosci. 4: 411-419. PMID: 12106349
- Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. | Parker, MA., et al. 2002. J Neurosci Res. 69: 39-50. PMID: 12111814
- Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. | Beauchamp, MH., et al. 2002. Invest Ophthalmol Vis Sci. 43: 3327-37. PMID: 12356842
- Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | Proudfoot, JM., et al. 2003. J Pharmacol Exp Ther. 305: 846-53. PMID: 12626661
- Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. | Thaete, LG., et al. 2003. J Soc Gynecol Investig. 10: 145-50. PMID: 12699876
- Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. | Clark, GD., et al. 1992. Neuron. 9: 1211-6. PMID: 1334422
- Platelet-activating factor stimulates arachidonic acid release and enhances thromboxane B2 production in intact fetal rat brain ex vivo. | Kunievsky, B. and Yavin, E. 1992. J Pharmacol Exp Ther. 263: 562-8. PMID: 1432689
- Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. | Sumita, C., et al. 2004. Biochim Biophys Acta. 1673: 115-21. PMID: 15279882
- Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. | Agrawal, V., et al. 2014. Biol Reprod. 91: 119. PMID: 25253732
- Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites. | Tessner, TG., et al. 1989. J Biol Chem. 264: 4794-9. PMID: 2538461
- Agonist-induced down-regulation of platelet-activating factor receptor gene expression in U937 cells. | Chau, LY., et al. 1994. Biochem J. 301 (Pt 3): 911-6. PMID: 7519853
- Platelet-activating factor biosynthesis induced by various stimuli in human HaCaT keratinocytes. | Travers, JB., et al. 1996. J Invest Dermatol. 107: 88-94. PMID: 8752845
Activator of:
PAF-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C-PAF (Carbamyl-PAF ), 5 mg | sc-201025 | 5 mg | $370.00 |