Bystin Antibody (A-10): sc-271722

Bystin Antibody (A-10) is a mouse monoclonal IgG3 kappa light chain antibody that detects Bystin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Bystin antibody (A-10) is available as a non-conjugated antibody. Bystin, also known as Bystin-like, is an evolutionarily conserved protein found from yeast to humans, playing a crucial role in ribosome biogenesis. Bystin primarily localizes in the nucleolus and cytoplasm, where Bystin associates with the 40S ribosomal subunit in the nucleus and directly binds to Trophinin and Tastin in the cytoplasm, facilitating the adhesion of cells expressing these proteins. Bystin′s cellular localization importance is highlighted by how Bystin knockdown not only inhibits cell proliferation but also delays RNA processing of the 18S component of the 40S ribosomal subunit, indicating Bystin′s essential role in forming functional ribosomes. Bystin expression knockdown leads to embryo development arrest around the 16-cell stage, highlighting Bystin′s significance in preimplantation embryonic development. Bystin overexpression in various human cancers suggests involvement in cell proliferation regulation, emphasizing Bystin′s potential as a therapeutic target.

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Bystin Antibody (A-10) References:

1. Trophinin, tastin, and bystin: a complex mediating unique attachment between trophoblastic and endometrial epithelial cells at their respective apical cell membranes.  |  Fukuda, MN. and Nozawa, S. 1999. Semin Reprod Endocrinol. 17: 229-34. PMID: 10797941
2. Recent molecular approaches to elucidate the mechanism of embryo implantation: trophinin, bystin, and tastin as molecules involved in the initial attachment of blastocysts to the uterus in humans.  |  Aoki, R. and Fukuda, MN. 2000. Semin Reprod Med. 18: 265-71. PMID: 11299965
3. Bystin as a novel marker for reactive astrocytes in the adult rat brain following injury.  |  Sheng, J., et al. 2004. Eur J Neurosci. 20: 873-84. PMID: 15305856
4. Bystin in perineural invasion of prostate cancer.  |  Ayala, GE., et al. 2006. Prostate. 66: 266-72. PMID: 16245277
5. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain.  |  Ma, L., et al. 2006. Eur J Neurosci. 23: 2265-76. PMID: 16706835
6. The Bysl gene product, bystin, is essential for survival of mouse embryos.  |  Aoki, R., et al. 2006. FEBS Lett. 580: 6062-8. PMID: 17055491
7. Crucial role of Bysl in mammalian preimplantation development as an integral factor for 40S ribosome biogenesis.  |  Adachi, K., et al. 2007. Mol Cell Biol. 27: 2202-14. PMID: 17242206
8. Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.  |  Miyoshi, M., et al. 2007. Biochem J. 404: 373-81. PMID: 17381424
9. Signal transduction in human embryo implantation.  |  Fukuda, MN. and Sugihara, K. 2007. Cell Cycle. 6: 1153-6. PMID: 17495530

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Bystin Antibody (A-10) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Bystin Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Bystin Antibody (A-10) Specifications

Alternate Product Name: Bystin

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 138-437

Epitope Target: Bystin

Epitope Species: human

Product Reactivity/Detection: Bystin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Bystin Antibody (A-10): N/A