BPAG1 Antibody (1B10): sc-293499

BPAG1 Antibody (1B10) is a mouse monoclonal IgG1 kappa light chain antibody that detects BPAG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-BPAG1 antibody (1B10) is available as the non-conjugated form. BPAG1 plays a crucial role in maintaining the integrity of the epidermal-dermal junction, particularly through its function in hemidesmosome formation, which is essential for cell adhesion in stratified squamous epithelia. Hemidesmosomes are specialized structures that anchor keratinocytes to the underlying basement membrane, and their proper assembly and disassembly are vital during processes such as wound healing, where basal cells migrate and differentiate. BPAG1 is characterized by a central rod domain flanked by globular regions, which contribute to structural stability and interaction with other cytoskeletal components. Notably, a neuronal isoform known as BPAG1n3 arises from differential splicing, featuring unique amino acid sequences that alter functional properties, including a modified actin-binding domain. This diversity in isoforms underscores BPAG1′s importance in various cellular contexts and potential implications in skin integrity and neurological functions.

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BPAG1 Antibody (1B10) References:

1. Integrators of the cytoskeleton that stabilize microtubules.  |  Yang, Y., et al. 1999. Cell. 98: 229-38. PMID: 10428034
2. Phorbol ester- and calcium-induced reorganization of 180-kDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron microscopy.  |  Kitajima, Y., et al. 1992. Exp Cell Res. 203: 17-24. PMID: 1426040
3. Mouse 230-kDa bullous pemphigoid antigen gene: structural and functional characterization of the 5'-flanking region and interspecies conservation of the deduced amino-terminal peptide sequence of the protein.  |  Sawamura, D., et al. 1994. J Invest Dermatol. 103: 651-5. PMID: 7963650
4. Redistribution of the hemidesmosome components alpha 6 beta 4 integrin and bullous pemphigoid antigens during epithelial wound healing.  |  Gipson, IK., et al. 1993. Exp Cell Res. 207: 86-98. PMID: 8319775
5. Internalization of the 180 kDa bullous pemphigoid antigen as immune complexes in basal keratinocytes: an important early event in blister formation in bullous pemphigoid.  |  Kitajima, Y., et al. 1998. Br J Dermatol. 138: 71-6. PMID: 9536225

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BPAG1 Antibody (1B10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BPAG1 Antibody (1B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BPAG1 Antibody (1B10) Specifications

Alternate Product Name: BPAG1

Product Clone Name: 1B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 401-500

Epitope Target: BPAG1

Epitope Species: human

Product Reactivity/Detection: BPAG1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BPAG1 Antibody (1B10): N/A