Bmx Antibody (E-2): sc-271025
- Bmx Antibody (E-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 81-300 mapping near the N-terminus of Bmx of human origin
- recommended for detection of Bmx of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Bmx Antibody (E-2) for WB applications. These reagents are now offered in bundles with Bmx Antibody (E-2) (see ordering information below).
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Bmx Antibody (E-2) is a mouse monoclonal IgG1 antibody that detects Bmx in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bmx is a member of the Tec family of non-receptor tyrosine kinases, which play crucial roles in various cellular processes, particularly in hematopoietic cells. Bmx (E-2) antibody targets a protein primarily located in the cytoplasm and highly expressed in the heart, where Bmx is involved in regulating cell signaling pathways that control cell growth and survival. Bmx′s cellular location enables interactions with other signaling molecules, thereby influencing processes such as apoptosis and proliferation. Dysregulation of Bmx has been implicated in various diseases, including cancer, making Bmx a significant target for therapeutic intervention. Anti-Bmx antibody (E-2) provides a reliable tool for researchers aiming to study the functional roles of Bmx in human health and disease, facilitating advancements in understanding cellular signaling networks.
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Bmx Antibody (E-2) References:
- BMX and its role in inflammation, cardiovascular disease, and cancer. | Cenni, B., et al. 2012. Int Rev Immunol. 31: 166-73. PMID: 22449076
- Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. | Holopainen, T., et al. 2015. Proc Natl Acad Sci U S A. 112: 13063-8. PMID: 26430242
- Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance. | Shi, Y., et al. 2018. Sci Transl Med. 10: PMID: 29848664
- BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer. | Chen, S., et al. 2018. Cancer Res. 78: 5203-5215. PMID: 30012673
- Nuclear localization of the tyrosine kinase BMX mediates VEGFR2 expression. | Liu, T., et al. 2020. J Cell Mol Med. 24: 126-138. PMID: 31642192
- BMX activates Wnt/β-catenin signaling pathway to promote cell proliferation and migration in breast cancer. | Li, K., et al. 2020. Breast Cancer. 27: 363-371. PMID: 31728872
- BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis. | Li, Z., et al. 2020. Circ Res. 126: 471-485. PMID: 31910739
- BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors. | Buelow, DR., et al. 2022. Blood Adv. 6: 5049-5060. PMID: 35797240
- BMX controls 3βHSD1 and sex steroid biosynthesis in cancer. | Li, X., et al. 2023. J Clin Invest. 133: PMID: 36647826
- BMX deletion mitigates neuroinflammation induced by retinal ischemia/reperfusion through modulation of the AKT/ERK/STAT3 signaling cascade. | Huang, G., et al. 2024. Heliyon. 10: e27114. PMID: 38434304
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bmx Antibody (E-2) | sc-271025 | 200 µg/ml | $322.00 | |||
Bmx Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-540192 | 200 µg Ab; 10 µg BP | $361.00 | |||
Bmx Antibody (E-2): m-IgG1 BP-HRP Bundle | sc-541960 | 200 µg Ab; 20 µg BP | $361.00 |