Bmx Antibody (D-6): sc-271706
- Bmx Antibody (D-6) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 643-671 at the C-terminus of Bmx of human origin
- recommended for detection of Bmx of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Bmx Antibody (D-6) for WB applications. These reagents are now offered in bundles with Bmx Antibody (D-6) (see ordering information below).
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Bmx Antibody (D-6) is a mouse monoclonal IgG3 antibody that detects Bmx in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bmx is a member of the Tec family of non-receptor tyrosine kinases, which play crucial roles in various cellular processes, including cell signaling and immune responses. Bmx (D-6) antibody targets a protein primarily located in the cytoplasm and particularly abundant in the heart, where Bmx is believed to be involved in regulating cardiac function and promoting cell survival under stress conditions. Bmx localization allows for rapid signaling responses to extracellular stimuli, which is essential for maintaining cellular homeostasis and responding to physiological challenges. Bmx (D-6) monoclonal antibody recognizes a protein that interacts with several key proteins, including phospholipase C-gamma and various adaptor proteins, further underscoring Bmx importance in signal transduction pathways. Anti-Bmx antibody (D-6) serves as an invaluable tool for researchers studying Bmx roles in health and disease, particularly in cardiovascular research and immune system function.
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Bmx Antibody (D-6) References:
- Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. | He, Y., et al. 2006. J Clin Invest. 116: 2344-55. PMID: 16932810
- Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. | Holopainen, T., et al. 2012. Cancer Res. 72: 3512-21. PMID: 22593188
- Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases. | Chen, S., et al. 2013. Sci Signal. 6: ra40. PMID: 23716717
- BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs. | Fox, JL. and Storey, A. 2015. Cancer Res. 75: 1345-55. PMID: 25649765
- miR-495 promotes the chemoresistance of SCLC through the epithelial-mesenchymal transition via Etk/BMX. | Wei, T., et al. 2017. Am J Cancer Res. 7: 628-646. PMID: 28401017
- BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. | Li, Y., et al. 2017. Oncotarget. 8: 49238-49252. PMID: 28514765
- BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway. | Xu, XF., et al. 2019. Cancer Cell Int. 19: 133. PMID: 31130822
- BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death. | Ko, HJ., et al. 2022. Cell Commun Signal. 20: 200. PMID: 36575468
- Vamorolone improves Becker muscular dystrophy and increases dystrophin protein in bmx model mice. | McCormack, NM., et al. 2023. iScience. 26: 107161. PMID: 37534133
- BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias. | Kaukonen, J., et al. 1996. Br J Haematol. 94: 455-60. PMID: 8790141
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bmx Antibody (D-6) | sc-271706 | 200 µg/ml | $322.00 | |||
Bmx Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-535030 | 200 µg Ab; 40 µg BP | $361.00 | |||
Bmx Antibody (D-6): m-IgG3 BP-HRP Bundle | sc-550303 | 200 µg Ab; 40 µg BP | $361.00 | |||
Bmx (D-6) Neutralizing Peptide | sc-271706 P | 100 µg/0.5 ml | $69.00 |