Blood Group H n/ab antigen Antibody (86-M): sc-52372

Blood Group H n/ab antigen Antibody (86-M) is a mouse monoclonal IgM antibody that detects Blood Group H n/ab antigen of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Blood Group H n/ab antigen (86-M) antibody is available as the non-conjugated form. Blood group antigens, including the H antigen, play a crucial role in cell recognition and signaling, as they are involved in various biological processes such as immune response and cellular communication. The H antigen serves as a precursor for the A and B antigens and is essential for the proper functioning of the ABO blood group system. Blood Group H n/ab antigen presence or absence can significantly impact blood transfusion compatibility and organ transplantation, making Blood Group H n/ab antigen vital for clinical applications. Additionally, blood group antigens are typically mucin-type and are found on erythrocytes, certain epithelial cells, and in the secretions of specific individuals. The modulation of these antigens during malignant cellular transformation highlights their importance in cancer biology, as these antigens can influence tumor progression and immune evasion. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A (1 and 2), B, H (1 and 2), M, N, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens, underscoring the complexity and significance of blood group antigens in both health and disease.

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Blood Group H n/ab antigen Antibody (86-M) References:

1. A novel function for a glucose analog of blood group H antigen as a mediator of leukocyte-endothelial adhesion via intracellular adhesion molecule 1.  |  Zhu, K., et al. 2003. J Biol Chem. 278: 21869-77. PMID: 12672794
2. Conversion of the human blood group H antigen to A antigen in vitro.  |  Yang, N. and Boettcher, B. 1991. Immunol Cell Biol. 69 (Pt 2): 111-8. PMID: 1717372
3. Expression of blood group H antigen type 2 chain by oral carcinoma cells after radiotherapy.  |  Shabana, AH., et al. 1987. Oral Surg Oral Med Oral Pathol. 63: 340-7. PMID: 3473361
4. Expression of blood group H antigen by normal, benign, and carcinoma cells of the oral epithelium: immunohistochemical study using monoclonal antibody RS13.  |  Shabana, AH., et al. 1986. Oral Surg Oral Med Oral Pathol. 62: 532-7. PMID: 3537896
5. Blood group H antigen of influenza A2 Virus.  |  Matsuzawa, S., et al. 1970. Nature. 226: 758. PMID: 5309798
6. Blood group H antigen with globo-series structure. Isolation and characterization from human blood group O erythrocytes.  |  Kannagi, R., et al. 1984. FEBS Lett. 175: 397-401. PMID: 6479351
7. Molecular dynamics simulation and NMR study of a blood group H trisaccharide.  |  Widmalm, G. and Venable, RM. 1994. Biopolymers. 34: 1079-88. PMID: 8075388
8. Recognition of the blood group H type 2 trisaccharide epitope by 28 monoclonal antibodies and three lectins.  |  Mollicone, R., et al. 1996. Glycoconj J. 13: 263-71. PMID: 8737251
9. Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gal alpha 1-3Gal), blood group H determinant and N-glycolylneuraminic acid.  |  Bouhours, D., et al. 1996. Glycoconj J. 13: 947-53. PMID: 8981086

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Blood Group H n/ab antigen Antibody (86-M) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Blood Group H n/ab antigen Antibody (86-M) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Blood Group H n/ab antigen Antibody (86-M) Specifications

Alternate Product Name: Blood Group H n/ab antigen

Product Clone Name: 86-M

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Blood Group H n/ab antigen

Epitope Species: human

Product Reactivity/Detection: Blood Group H n/ab antigen

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Blood Group H n/ab antigen Antibody (86-M): N/A