Molecular structure of Bis(2-mercaptoethyl)sulfone, CAS Number: 145626-87-5
Bis(2-mercaptoethyl)sulfone (CAS 145626-87-5)
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Alternate Names:
BMS
Application:
Bis(2-mercaptoethyl)sulfone is a disulfide reducing agent replacement for DTT
CAS Number:
145626-87-5
Purity:
≥96%
Molecular Weight:
186.32
Molecular Formula:
C4H10O2S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Bis(2-mercaptoethyl)sulfone (BMS) is a symmetric bisthiol sulfone compound. Bis(2-mercaptoethyl)sulfone has been described as a useful compound for the reduction of disulfides in aqueous solutions. Also, Bis(2-mercaptoethyl)sulfone is a water-soluble reagent that is useful for the reduction of native disulfide bonds in proteins. It is considered to be a superior reducing agent to DTT. Bis(2-mercaptoethyl)sulfone has shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in alpha-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.
Bis(2-mercaptoethyl)sulfone (CAS 145626-87-5) References
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- Breaking a Couple: Disulfide Reducing Agents. | Mthembu, SN., et al. 2020. Chembiochem. 21: 1947-1954. PMID: 32196882
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- Selenol-catalyzed reduction of disulfide bonds in peptides and proteins | Singh, R. 1996. Techniques in Protein Chemistry. 7: 221-230.
- Recombinant Lactobacillus leichmannii ribonucleosidetriphosphate reductase as biocatalyst in the preparative synthesis of 2′-deoxyribonucleoside-5′-triphosphates | Brunella, A., & Ghisalba, O. 2000. Journal of Molecular Catalysis B: Enzymatic. 10(1-3): 215-222.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bis(2-mercaptoethyl)sulfone, 1 g | sc-210935 | 1 g | $765.00 |