Molecular structure of BI-6C9, CAS Number: 791835-21-7
BI-6C9 (CAS 791835-21-7)
See product citations (3)
Alternate Names:
N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide
Application:
BI-6C9 is a tBid inhibitor that possesses antiapoptotic properties
CAS Number:
791835-21-7
Purity:
≥97% (HPLC)
Molecular Weight:
471.59
Molecular Formula:
C23H25N3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BI-6C9 is a small molecule inhibitor that targets a specific protein involved in cellular signaling pathways. It is currently being studied for its potential role in modulating cellular processes related to cell growth and proliferation. BI-6C9 has a high affinity for its target, making it to study the function of this protein in biological systems. BI-6C9 represents a novel and promising avenue for investigating the role of specific proteins in cellular function.
BI-6C9 (CAS 791835-21-7) References
- tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. | Wei, MC., et al. 2000. Genes Dev. 14: 2060-71. PMID: 10950869
- Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules. | Becattini, B., et al. 2004. Chem Biol. 11: 1107-17. PMID: 15324812
- Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. | Grohm, J., et al. 2010. Brain Behav Immun. 24: 831-8. PMID: 19961923
- Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells. | Miyake, K., et al. 2012. Biochim Biophys Acta. 1823: 1378-88. PMID: 22683989
- Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. | Zhou, H., et al. 2014. Mol Cancer. 13: 59. PMID: 24628719
- Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma. | Zhang, CZ., et al. 2015. Invest New Drugs. 33: 1-11. PMID: 25200916
- Detergent Sclerosants Stimulate Leukocyte Apoptosis and Oncosis. | Cooley-Andrade, O., et al. 2016. Eur J Vasc Endovasc Surg. 51: 846-56. PMID: 27067723
- BID links ferroptosis to mitochondrial cell death pathways. | Neitemeier, S., et al. 2017. Redox Biol. 12: 558-570. PMID: 28384611
- Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis. | Jelinek, A., et al. 2018. Free Radic Biol Med. 117: 45-57. PMID: 29378335
- Characterization of Novel Diphenylamine Compounds as Ferroptosis Inhibitors. | Hinder, L., et al. 2021. J Pharmacol Exp Ther. 378: 184-196. PMID: 34011530
- Diverse Mechanisms of Resistance against Osimertinib, a Third-Generation EGFR-TKI, in Lung Adenocarcinoma Cells with an EGFR-Activating Mutation. | Nishihara, S., et al. 2022. Cells. 11: PMID: 35883645
- Organelle-Specific Mechanisms in Crosstalk between Apoptosis and Ferroptosis. | Wu, P., et al. 2023. Oxid Med Cell Longev. 2023: 3400147. PMID: 36644574
- The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis. | Pu, Z., et al. 2023. Phytomedicine. 114: 154753. PMID: 37084628
Inhibitor of:
Apoptosis, and BID.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BI-6C9, 1 mg | sc-210915 | 1 mg | $67.00 | |||
BI-6C9, 5 mg | sc-210915A | 5 mg | $296.00 |