Molecular structure of Benazepril Free base, CAS Number: 86541-75-5
Benazepril Free base (CAS 86541-75-5)
Alternate Names:
2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
Application:
Benazepril Free base is a non-sulfhydryl ACE inhibitor
CAS Number:
86541-75-5
Purity:
≥95%
Molecular Weight:
424.49
Molecular Formula:
C24H28N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Benazepril Free base is an inhibitor of ACE (angiotensin-converting enzyme). This blocks the conversion of angiotensin I to angiotensin II, which in turn prevents vasoconstriction associated with activation of angiotensin II receptors. ACE inhibition causes vasodilation and an increase in capillary blood volume.
Benazepril Free base (CAS 86541-75-5) References
- Benazepril inhibited the NF-κB and TGF-β networking on LV hypertrophy in rats. | Yan, SH., et al. 2013. Immunol Lett. 152: 126-34. PMID: 23707880
- Benazepril affects integrin-linked kinase and smooth muscle α-actin expression in diabetic rat glomerulus and cultured mesangial cells. | Niu, H., et al. 2014. BMC Nephrol. 15: 135. PMID: 25142208
- Benazepril in dogs with asymptomatic mitral valve disease. | Brennan, M. and Stavisky, J. 2015. Vet Rec. 177: 392. PMID: 26475899
- Development and validation of different methods manipulating zero order and first order spectra for determination of the partially overlapped mixture benazepril and amlodipine: A comparative study. | Hemdan, A. 2016. Spectrochim Acta A Mol Biomol Spectrosc. 164: 52-60. PMID: 27078209
- Attenuation of the blood pressure response to exogenous angiotensin I after oral administration of benazepril to healthy adult horses. | Afonso, T., et al. 2017. Equine Vet J. 49: 358-362. PMID: 27224673
- Effect of benazepril and robenacoxib and their combination on glomerular filtration rate in dogs. | Panteri, A., et al. 2017. J Vet Pharmacol Ther. 40: 44-56. PMID: 27302598
- Effect of benazepril, robenacoxib and their combination on glomerular filtration rate in cats. | King, JN., et al. 2016. BMC Vet Res. 12: 124. PMID: 27338786
- Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses. | Serrano-Rodríguez, JM., et al. 2017. Res Vet Sci. 114: 117-122. PMID: 28371693
- Effects of Benazepril on Survival of Dogs with Chronic Kidney Disease: A Multicenter, Randomized, Blinded, Placebo-Controlled Clinical Trial. | King, JN., et al. 2017. J Vet Intern Med. 31: 1113-1122. PMID: 28669137
- Effect of benazepril and pimobendan on serum angiotensin-converting enzyme activity in dogs. | King, JN., et al. 2018. J Vet Pharmacol Ther. 41: 485-489. PMID: 29392741
- [The influence of benazepril and amlodipine on the expression of secretin and somatostatin in spontaneously hypertensive rats]. | Jin, H., et al. 2018. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 34: 154-158. PMID: 29926681
- Effect of spironolactone and benazepril on furosemide-induced diuresis and renin-angiotensin-aldosterone system activation in normal dogs. | Adin, D., et al. 2021. J Vet Intern Med. 35: 1245-1254. PMID: 33713485
- [Effect of moxibustion combined with benazepril on expression of IL-18 and phosphorylated protein kinase B in myocardial tissue of rats with chronic heart failure]. | Wang, W., et al. 2021. Zhen Ci Yan Jiu. 46: 935-41. PMID: 34865330
Inhibitor of:
ACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benazepril Free base, 1 g | sc-337551 | 1 g | $1040.00 |