Molecular structure of Avarol, CAS Number: 55303-98-5
Avarol (CAS 55303-98-5)
Application:
Avarol is a cytostatic agent which has potent antileukemic activity
CAS Number:
55303-98-5
Purity:
≥97%
Molecular Weight:
314.5
Molecular Formula:
C21H30O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Avarol functions as a potent inhibitor of protein prenylation. By interfering with protein prenylation, Avarol effectively disrupts the proper functioning of key signaling pathways within the cell, ultimately leading to a cascade of downstream effects on cellular processes. Avarol′s mechanism of action involves binding to the prenyltransferase enzymes, thereby preventing the transfer of prenyl groups onto target proteins. As a result, Avarol disrupts the proper localization and function of prenylated proteins, leading to significant alterations in cellular signaling and regulation.
Avarol (CAS 55303-98-5) References
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- Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone. | Sarin, PS., et al. 1987. J Natl Cancer Inst. 78: 663-6. PMID: 2435942
- Suppression of the modulatory effects of the antileukemic and anti-human immunodeficiency virus compound avarol on gene expression by tryptophan. | Schröder, HC., et al. 1989. Cancer Res. 49: 2069-76. PMID: 2495175
- Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol. | Pejin, B., et al. 2014. Curr Pharm Biotechnol. 15: 583-8. PMID: 25213366
- Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes. | Müller, WE., et al. 1986. Eur J Cancer Clin Oncol. 22: 473-6. PMID: 3488220
- Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo. | Müller, WE., et al. 1985. Cancer Res. 45: 4822-6. PMID: 3839712
- Antimutagenic activity of the novel antileukemic agents, avarone and avarol. | Kurelec, B., et al. 1985. Mutat Res. 144: 63-6. PMID: 3900707
- Avarol and avarone, two new anti-inflammatory agents of marine origin. | Ferrándiz, ML., et al. 1994. Eur J Pharmacol. 253: 75-82. PMID: 8013550
- In vitro effect of avarone and avarol, a quinone/hydroquinone couple of marine origin, on platelet aggregation. | Belisario, MA., et al. 1996. Pharmacol Toxicol. 79: 300-4. PMID: 9000256
Inhibitor of:
Cox, group II sPLA2, and LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Avarol, 1 mg | sc-202480 | 1 mg | $133.00 |