AsnRS Antibody (G-8): sc-271059

AsnRS Antibody (G-8) is a mouse monoclonal IgM antibody that detects AsnRS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-AsnRS antibody (G-8) is available as the non-conjugated monoclonal isotype antibody. AsnRS protein, also known as cytoplasmic asparaginyl-tRNA synthetase, is encoded by the human gene NARS and plays a crucial role in protein synthesis by catalyzing the attachment of asparagine to its corresponding tRNA. This process is vital for the accurate translation of genetic information into proteins, as it ensures that the correct amino acids are incorporated into the growing polypeptide chain. AsnRS belongs to the class-II aminoacyl-tRNA synthetase family, which is characterized by its ability to recognize specific amino acids and their cognate tRNAs, thereby maintaining the fidelity of protein synthesis. AsnRS is primarily located in the cytoplasm, where AsnRS interacts with various tRNA molecules to facilitate the charging process. Notably, AsnRS autoantibodies have been linked to interstitial lung disease, highlighting AsnRS′s potential role in autoimmune conditions. Understanding the function and importance of AsnRS is essential for elucidating its involvement in both normal cellular processes and disease states, making AsnRS (G-8) monoclonal antibody a valuable tool for researchers studying these mechanisms.

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AsnRS Antibody (G-8) References:

1. Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2.  |  Ramirez, BL., et al. 2006. J Infect Dis. 193: 1164-71. PMID: 16544258
2. Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change.  |  Sukuru, SC., et al. 2006. J Comput Aided Mol Des. 20: 159-78. PMID: 16645791
3. Structural basis of the water-assisted asparagine recognition by asparaginyl-tRNA synthetase.  |  Iwasaki, W., et al. 2006. J Mol Biol. 360: 329-42. PMID: 16753178
4. The nondiscriminating aspartyl-tRNA synthetase from Helicobacter pylori: anticodon-binding domain mutations that impact tRNA specificity and heterologous toxicity.  |  Chuawong, P. and Hendrickson, TL. 2006. Biochemistry. 45: 8079-87. PMID: 16800632
5. Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase.  |  Hirakata, M., et al. 2007. Arthritis Rheum. 56: 1295-303. PMID: 17393393
6. Structure of the nondiscriminating aspartyl-tRNA synthetase from the crenarchaeon Sulfolobus tokodaii strain 7 reveals the recognition mechanism for two different tRNA anticodons.  |  Sato, Y., et al. 2007. Acta Crystallogr D Biol Crystallogr. 63: 1042-7. PMID: 17881821

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AsnRS Antibody (G-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AsnRS Antibody (G-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AsnRS Antibody (G-8) Specifications

Alternate Product Name: AsnRS

Product Clone Name: G-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1-289

Epitope Target: AsnRS

Epitope Species: human

Product Reactivity/Detection: AsnRS

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AsnRS Antibody (G-8): N/A