ASGPR2/Asialoglycoprotein Receptor 2/ASGR2 Antibody (3-YD7): sc-134273
- ASGPR2/Asialoglycoprotein Receptor 2/ASGR2 Antibody (3-YD7) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant ASGPR2 protein of human origin
- recommended for detection of ASGPR2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ASGPR2/Asialoglycoprotein Receptor 2/ASGR2 Antibody (3-YD7). This work is in progress.
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ASGPR2 Antibody (3-YD7) is a mouse monoclonal IgG2a antibody that detects asialoglycoprotein receptor 2 (ASGPR2) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ASGPR2 is a crucial component of the asialoglycoprotein receptor complex, which plays a significant role in the liver′s ability to clear glycoproteins from circulation. Anti-ASGPR2 antibody (3-YD7) recognizes a receptor primarily located on the surface of hepatic cells, where ASGPR2 facilitates the endocytosis of glycoproteins that have terminal galactose and N-acetylgalactosamine residues, a process vital for maintaining homeostasis and regulating protein levels in the bloodstream. The internalization of these glycoproteins not only aids in their degradation but also prevents their accumulation, which could lead to pathological conditions. ASGPR2′s ability to bind to hepatitis B virus (HBV) highlights its importance in viral pathogenesis, making ASGPR2 a potential target for therapeutic interventions aimed at treating HBV infections. ASGPR2 monoclonal antibody (3-YD7) serves as an essential tool for researchers investigating liver function, glycoprotein metabolism, and viral interactions in human health and disease.
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ASGPR2/Asialoglycoprotein Receptor 2/ASGR2 Antibody (3-YD7) References:
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- Novel SARS-CoV-2 receptors: ASGR1 and KREMEN1. | Hoffmann, M. and Pöhlmann, S. 2022. Cell Res. 32: 1-2. PMID: 34903854
- Asialoglycoprotein Receptor 2 Expression in Patients With Locally Advanced Gastric Cancer After Curative Resection. | Oshima, T., et al. 2024. Anticancer Res. 44: 397-402. PMID: 38159992
- Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes. | Yang, X., et al. 2024. Signal Transduct Target Ther. 9: 42. PMID: 38355848
- Comparative studies of mouse (HL-2) and human (HL-A) histocompatibility antigens. | Hess, M. and Smith, W. 1974. Eur J Biochem. 43: 471-7. PMID: 4831971
- High-affinity ligand binding to subunit H1 of the asialoglycoprotein receptor in the absence of subunit H2. | Bider, MD., et al. 1995. Eur J Biochem. 230: 207-12. PMID: 7541348
- The oligomerization domain of the asialoglycoprotein receptor preferentially forms 2:2 heterotetramers in vitro. | Bider, MD., et al. 1996. J Biol Chem. 271: 31996-2001. PMID: 8943247
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ASGPR2/Asialoglycoprotein Receptor 2/ASGR2 Antibody (3-YD7) | sc-134273 | 100 µg/ml | $333.00 |