Arvanil is a cannabinoid CB1 and VR1 (vanilloid TRPV1) agonist (Ki values are 0.5 and 0.3 μM respectively). Arvanil as a vanilloid analog is 100-fold more potent than Anandamide in producing hypothermia, catalepsy and inhibiting spontaneous activity when administered to mice. Arvanil also inhibits the anandamide transporter (IC50 = 3.6 μM). Furthermore, Arvanil is reported to induce apoptosis. Arvanil is an inhibitor of FAAH.
1. Di Marzo, V., et al. 2000. Eur. J. Pharmacol. 406: 363-374. PMID: 11040343 2. Melck, D., et al. 1999. Biochem. Biophys. Res. Commun. 262: 275-284. PMID: 10448105 3. De Petrocellis, L., et al. 2000. FEBS Lett. 483: 52-56. PMID: 11033355
Stock solutions are stable for up to 3 months at -20°C when stored under an atmosphere of argon or nitrogen.
Soluble in DMSO (40 mg/ml), and ethanol (20 mg/ml).
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