ARH Antibody (Q-13): sc-100653

ARH Antibody (Q-13) is a mouse monoclonal IgG1 antibody that detects ARH (autosomal recessive hypercholesterolemia protein) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ARH is a 308 amino acid cytoplasmic protein characterized by one PID domain, playing a crucial role as an adapter protein that facilitates efficient endocytosis of low-density lipoprotein receptor (LDLR) from coated pits in polarized cells, such as hepatocytes and lymphocytes. By stabilizing the interaction between LDLR and structural components of these pits, ARH is essential for maintaining cholesterol homeostasis in the body. ARH expression is predominantly found in kidney, liver, and placenta, with significantly lower levels in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes. Mutations in the ARH gene lead to autosomal recessive hypercholesterolemia, a condition marked by defective internalization of LDL receptors in the liver, resulting in clinical manifestations similar to familial hypercholesterolemia, including markedly elevated plasma LDL cholesterol levels, formation of tuberous and tendon xanthomata, and increased risk of premature atherosclerosis. Anti-ARH antibody (Q-13) is an invaluable tool for researchers investigating mechanisms of cholesterol metabolism and related disorders.

The preferred ARH antibody is ARH Antibody (F-11): sc-514106.