Molecular structure of Arachidonoyl Thio-PC, CAS Number: 146797-82-2
Arachidonoyl Thio-PC (CAS 146797-82-2)
Alternate Names:
2-deoxy-2-thio Arachidonoyl PC
Application:
Arachidonoyl Thio-PC is a substrate for phospholipase A2
CAS Number:
146797-82-2
Purity:
>98%
Molecular Weight:
784.2
Molecular Formula:
C44H82NO6PS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Arachidonoyl Thio-PC is a substrate for all forms of phospholipase A2 (PLA2) including the cytosolic, Ca2+-dependent form (cPLA2). Upon hydrolysis of the thioester bond, free thiols are detected using DTNB (Ellmans reagent)
Arachidonoyl Thio-PC (CAS 146797-82-2) References
- Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain. | Bosetti, F., et al. 2003. J Neurochem. 85: 690-6. PMID: 12694395
- Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | Beck-Speier, I., et al. 2003. Prostaglandins Other Lipid Mediat. 71: 217-34. PMID: 14518563
- Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha. | Saiga, A., et al. 2005. Prostaglandins Other Lipid Mediat. 75: 79-89. PMID: 15789617
- Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain. | Ma, L., et al. 2010. J Pharmacol Exp Ther. 333: 540-6. PMID: 20123931
- Decrease in expression or activity of cytosolic phospholipase A2alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. | Niknami, M., et al. 2010. Biochim Biophys Acta. 1801: 731-7. PMID: 20227521
- Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells. | Sundarraj, S., et al. 2012. J Cancer Res Clin Oncol. 138: 827-35. PMID: 22274867
- Inhibition of neutral sphingomyelinase decreases arachidonic acid mediated inflammation in liver ischemia-reperfusion injury. | Aslan, M., et al. 2014. Int J Clin Exp Pathol. 7: 7814-23. PMID: 25550821
- Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. | Biernacki, M., et al. 2016. Toxicol Appl Pharmacol. 301: 31-41. PMID: 27086176
- Effect of tauroursodeoxycholic acid on PUFA levels and inflammation in an animal and cell model of hepatic endoplasmic reticulum stress. | Aslan, M., et al. 2018. Hum Exp Toxicol. 37: 803-816. PMID: 29027487
- Ursodeoxycholyl lysophosphatidylethanolamide protects against hepatic ischemia/reperfusion injury via phospholipid metabolism-mediated mitochondrial quality control. | Gu, J., et al. 2020. FASEB J. 34: 6198-6214. PMID: 32162746
- Activation of the cytosolic calcium-independent phospholipase A2 β isoform contributes to TRPC6 externalization via release of arachidonic acid. | Putta, P., et al. 2021. J Biol Chem. 297: 101180. PMID: 34509476
- iPLA2 inhibition blocks LysoPC-induced TRPC6 externalization and promotes Re-endothelialization of carotid injuries in hypercholesterolemic mice. | Putta, P., et al. 2023. Cell Calcium. 112: 102734. PMID: 37030190
- 1-Hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine as a substrate for the microtiterplate assay of human cytosolic phospholipase A2. | Reynolds, LJ., et al. 1994. Anal Biochem. 217: 25-32. PMID: 8203736
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arachidonoyl Thio-PC, 5 mg | sc-202063 | 5 mg | $250.00 |