Molecular structure of APHS, CAS Number: 209125-28-0
APHS (CAS 209125-28-0)
Alternate Names:
N′-(3-aminopropyl)homospermidine
Application:
APHS is a anti-inflammatory, selective, and potent Cox-2 inhibitor
CAS Number:
209125-28-0
Molecular Weight:
262.40
Molecular Formula:
C15H18O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
APHS is a selective inhibitor of Cox-2 (cyclooxygenase-2) that covalently modifies the enzyme by Ser-530 acetylation. APHS is described to be 60 times as reactive and 100 times as selective for Cox-2 as compared to aspirin. APHS is demonstrated to block HIV-1 replication and indicated to operate through interaction with the reverse transcription process of HIV-1 proliferation.
APHS (CAS 209125-28-0) References
- Cyclooxygenase inhibitors--current status and future prospects. | Dannhardt, G. and Kiefer, W. 2001. Eur J Med Chem. 36: 109-26. PMID: 11311743
- Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide. | Phillip Hochgesang, G., et al. 2003. Arch Biochem Biophys. 409: 127-33. PMID: 12464251
- Neuroprotection of cultured cortical neurons mediated by the cyclooxygenase-2 inhibitor APHS can be reversed by a prostanoid. | Carlson, NG. 2003. J Neurosci Res. 71: 79-88. PMID: 12478616
- Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication. | Pereira, CF., et al. 2003. Antiviral Res. 58: 253-63. PMID: 12767473
- Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. | Sennlaub, F., et al. 2003. Circulation. 108: 198-204. PMID: 12821538
- Neuroinflammation, COX-2, and ALS--a dual role? | Consilvio, C., et al. 2004. Exp Neurol. 187: 1-10. PMID: 15081582
- Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors. | Uddin, MJ., et al. 2004. Bioorg Med Chem. 12: 5929-40. PMID: 15498669
- Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors. | Chen, QH., et al. 2005. Bioorg Med Chem. 13: 2459-68. PMID: 15755648
- Ligand-based design, synthesis and primary in vivo screening of pyrrole derivatives as potential tricyclic anti-inflammatory agents. | Bijev, A., et al. 2006. Arzneimittelforschung. 56: 753-9. PMID: 17220053
- Computational determination of binding modes of 2-acetoxyphenylhept-2-ynyl sulfide to cyclooxygenase-2. | Wei, W., et al. 2020. J Biomol Struct Dyn. 38: 3648-3658. PMID: 31498032
- Aspirin-like molecules that covalently inactivate cyclooxygenase-2. | Kalgutkar, AS., et al. 1998. Science. 280: 1268-70. PMID: 9596581
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
APHS, 10 mg | sc-200668 | 10 mg | $330.00 | |||
APHS, 100 mg | sc-200668B | 100 mg | $2045.00 |