Antibiotic TAN 420C (CAS 91700-91-3)

Antibiotic TAN 420C is a secondary metabolite produced by Streptomyces species, known for its potent antibacterial activity against Gram-positive bacteria. It exerts its effects by inhibiting bacterial protein synthesis, specifically targeting the 50S ribosomal subunit. This action interferes with the elongation phase of protein synthesis, leading to the disruption of bacterial growth and replication. In research, TAN 420C has been utilized to study the mechanisms of bacterial resistance to protein synthesis inhibitors, providing valuable insights into the development of new antibiotics. Additionally, it serves as a model compound for investigating ribosomal function and structure, aiding in the understanding of ribosome-targeting antibiotics. TAN 420C has also been used to probe the interactions between ribosomal RNA and antibiotics, contributing to the elucidation of binding sites and resistance mechanisms at the molecular level. Furthermore, it has been employed in studies exploring the regulation of bacterial gene expression in response to protein synthesis inhibition. Its use in microbial ecology research helps to understand the competitive dynamics and interactions within microbial communities, particularly in soil environments where Streptomyces species are prevalent. Overall, Antibiotic TAN 420C continues to be a valuable tool in microbiology and molecular biology research, advancing our knowledge of bacterial protein synthesis and antibiotic resistance.