AMDHD1 Antibody (F-3): sc-515501

AMDHD1 Antibody (F-3) is a mouse monoclonal IgM antibody that detects AMDHD1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-AMDHD1 antibody (F-3) is available as the non-conjugated monoclonal isotype antibody. AMDHD1, also known as probable imidazolonepropionase, consists of 426 amino acids and belongs to the hutI family, playing a crucial role in hydrolase activity that acts on carbon-nitrogen bonds, excluding peptide bonds, particularly in cyclic amides. AMDHD1 is essential for imidazolonepropionase activity and is involved in metal ion binding, specifically binding one iron or zinc ion per subunit, which is vital for enzymatic function. AMDHD1 is located on human chromosome 12, a region associated with various skeletal deformities and developmental disorders, including Noonan syndrome, which is characterized by heart and facial developmental defects. AMDHD1′s significance extends beyond enzymatic activity, as AMDHD1 is implicated in critical biological processes that can influence cellular function and development, making AMDHD1 a valuable target for research in both basic and clinical settings.

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AMDHD1 Antibody (F-3) References:

1. The genomic context of natural killer receptor extended gene families.  |  Trowsdale, J., et al. 2001. Immunol Rev. 181: 20-38. PMID: 11513141
2. The phenotypic spectrum of COL2A1 mutations.  |  Nishimura, G., et al. 2005. Hum Mutat. 26: 36-43. PMID: 15895462
3. Comparative genomics of natural killer cell receptor gene clusters.  |  Kelley, J., et al. 2005. PLoS Genet. 1: 129-39. PMID: 16132082
4. Noonan syndrome.  |  van der Burgt, I. 2007. Orphanet J Rare Dis. 2: 4. PMID: 17222357
5. [Mutation analysis of PTPN11 gene in Noonan syndrome].  |  Yang, T., et al. 2010. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 27: 554-8. PMID: 20931536
6. Low basal transcripts of the COL2A1 collagen gene from lymphoblasts show alternative splicing of exon 12 in the Kniest form of spondyloepiphyseal dysplasia.  |  Yang, W. and Cole, WG. 1998. Hum Mutat. Suppl 1: S1-2. PMID: 9452022

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AMDHD1 Antibody (F-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AMDHD1 Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AMDHD1 Antibody (F-3) Specifications

Alternate Product Name: AMDHD1

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 133-359

Epitope Target: AMDHD1

Epitope Species: human

Product Reactivity/Detection: AMDHD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AMDHD1 Antibody (F-3): N/A