α-tectorin Antibody (2A5): sc-517128

α-tectorin Antibody (2A5) is a mouse monoclonal IgG2a kappa light chain antibody that detects alpha-tectorin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-alpha-tectorin antibody (2A5) is available as a non-conjugated format. Alpha-tectorin protein, also known as TECTA, plays a crucial role as a non-collagenous component of the tectorial membrane, an essential extracellular matrix structure in the inner ear. This membrane covers the cochlea′s neuroepithelium and interacts with the stereocilia bundles of specialized sensory hair cells, facilitating the conversion of sound waves into electrical signals. The movement of these hair cells in relation to the tectorial membrane is vital for auditory transduction, as the deflection of stereocilia leads to fluctuations in hair-cell membrane potential. Alpha-tectorin can form both homomeric and heteromeric filaments through self-association or interaction with beta-tectorin, which is significant for maintaining the structural integrity of the tectorial membrane. Mutations in the alpha-tectorin gene have been linked to autosomal dominant non-syndromic sensorineural deafness, with the specific localization of these mutations within different protein modules potentially leading to varied clinical manifestations.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

α-tectorin Antibody (2A5) References:

1. Studies on experimental coronary insufficiency. II. Effects of beta-adrenergic blocking agent (propranolol) on metabolic response to adrenaline and noradrenaline in dogs with coronary constriction.  |  Iimura, O., et al. Recent Adv Stud Cardiac Struct Metab. 12: 543-7. PMID: 1032009
2. A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback.  |  Legan, PK., et al. 2000. Neuron. 28: 273-85. PMID: 11087000
3. Quantification of TECTA and DFNA5 expression in the developing mouse cochlea.  |  Maeda, Y., et al. 2001. Neuroreport. 12: 3223-6. PMID: 11711860
4. Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss.  |  Iwasaki, S., et al. 2002. Arch Otolaryngol Head Neck Surg. 128: 913-7. PMID: 12162770
5. A genotype-phenotype correlation with gender-effect for hearing impairment caused by TECTA mutations.  |  Pfister, M., et al. 2004. Cell Physiol Biochem. 14: 369-76. PMID: 15319541
6. A deafness mutation isolates a second role for the tectorial membrane in hearing.  |  Legan, PK., et al. 2005. Nat Neurosci. 8: 1035-42. PMID: 15995703