α-tectorin Activators
α-Tectorin is a critical component of the tectorial membrane in the cochlea of the inner ear, playing a pivotal role in the mechanics of hearing. It is a large extracellular matrix glycoprotein that contributes to the unique biomechanical properties of the tectorial membrane, essential for translating sound waves into neural signals. The integrity and functionality of α-tectorin are crucial for the proper vibration and mechanical coupling between the tectorial membrane and the sensory hair cells, which are the primary transducers of auditory signals. Any alteration in the structure or function of α-tectorin can significantly impact hearing sensitivity and frequency resolution, underscoring the importance of maintaining its functional state for auditory health.
The general mechanisms of activation for proteins like α-tectorin, particularly in the absence of direct chemical activators, involve influencing the biochemical and cellular pathways that support its proper folding, assembly, and integration into the tectorial membrane. These pathways include calcium signaling, which is essential for cochlear function and can enhance the processes that stabilize α-tectorin; magnesium and zinc, which contribute to cellular stability and protein structure, respectively; and elements like copper and selenium, which play roles in enzymatic activities and antioxidant defense, crucial for maintaining the functional integrity of α-tectorin. The indirect activation of α-tectorin, therefore, relies on maintaining optimal conditions for its expression, post-translational modifications, and assembly into the tectorial membrane, ensuring its contribution to the precise mechanics of hearing. This approach highlights the complexity of targeting specific proteins within intricate biological systems, where direct activators are unavailable, and underscores the necessity of a broader understanding of the biochemical and cellular context to support protein function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium signaling is crucial for cochlear function. Increased intracellular calcium can activate cellular processes that enhance the stability and function of α-tectorin in the tectorial membrane, contributing to improved hearing mechanics. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium is involved in numerous cellular processes, including those affecting the ear's inner structures. By stabilizing cells and reducing excitotoxicity, magnesium sulfate can support the integrity and function of α-tectorin. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc plays a key role in maintaining the structure and function of proteins. Zinc sulfate can contribute to the structural integrity of α-tectorin, ensuring its proper function in the tectorial membrane of the cochlea. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Fluoride ions can influence mineralization processes, which are crucial for the inner ear's structure. Enhanced mineralization could indirectly support the functional activation of α-tectorin by improving the cochlear mechanics. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper is essential for enzymatic activities that could affect the ear's biochemistry. Through its enzymatic role, copper(II) sulfate might enhance the biochemical pathways that lead to the functional activation of α-tectorin. | ||||||
Potassium iodide | 7681-11-0 | sc-203356 sc-203356A sc-203356B sc-203356C sc-203356D | 100 g 500 g 2.5 kg 10 kg 25 kg | $35.00 $125.00 $500.00 $1950.00 $3500.00 | 1 | |
Iodide ions are critical for thyroid function, which can influence auditory function. Proper thyroid function can indirectly support α-tectorin′s role in hearing by ensuring optimal metabolic conditions for its activity. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is crucial for antioxidant defense systems. By enhancing cellular antioxidant capacity, selenium dioxide can protect α-tectorin from oxidative damage, thus maintaining its functional activity in the ear. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $40.00 $105.00 | ||
Manganese is involved in the formation of connective tissue and bone. In the context of the ear, manganese(II) sulfate could support the structures that are essential for α-tectorin's proper function and activation. | ||||||
Chromium(III) chloride | 10025-73-7 | sc-239548 sc-239548A sc-239548B | 25 g 100 g 1 kg | $68.00 $272.00 $2462.00 | ||
Chromium influences glucose metabolism, which is vital for energy-dependent processes in the ear. Improved metabolic efficiency can support the cellular processes that activate α-tectorin function. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Cobalt is part of vitamin B12, which is essential for neurological function. Improved neurological function can indirectly enhance the auditory processing in which α-tectorin plays a critical role. | ||||||