Alatrofloxacin mesylate (CAS 146961-77-5)

Alatrofloxacin mesylate, a fluoroquinolone antibiotic derivative, has been a subject of scientific research primarily due to its antimicrobial activity and potential mechanisms of action. Recent studies have focused on elucidating its mechanism of action at the molecular level, revealing its ability to inhibit bacterial DNA gyrase and topoisomerase IV enzymes. Alatrofloxacin mesylate exerts its bactericidal effects by binding to the DNA gyrase subunit A and topoisomerase IV, preventing the relaxation of supercoiled DNA during DNA replication and transcription processes. This inhibition leads to the accumulation of double-stranded breaks in bacterial DNA, ultimately resulting in bacterial cell death. Moreover, researchers have investigated the structure-activity relationships of fluoroquinolone derivatives, including alatrofloxacin mesylate, aiming to optimize their pharmacological properties and enhance their efficacy against resistant bacterial strains. Additionally, alatrofloxacin mesylate has been utilized as a tool compound in microbiology research to study bacterial resistance mechanisms and explore potential strategies for combating antibiotic resistance. Its mechanism of action against bacterial DNA gyrase and topoisomerase IV, along with its broad-spectrum antimicrobial activity, make alatrofloxacin mesylate a valuable asset in antimicrobial research, offering insights into bacterial cell biology and potential approaches for overcoming antibiotic resistance.