AGP-1 Antibody (GPB2): sc-51754

AGP-1 Antibody (GPB2) is a mouse monoclonal IgG1 antibody that detects AGP-1 protein of bovine origin by western blotting (WB). AGP-1, or α1-acid glycoprotein, is a crucial acute phase plasma protein synthesized in the liver, playing a significant role in the body′s response to inflammation and infection. AGP-1 (GPB2) antibody is essential for regulating the interaction between blood cells and endothelial cells, facilitating the extravasation of immune cells during inflammatory responses. Notably, AGP-1 undergoes post-translational modifications, including glycosylation, which can influence stability, activity, and interactions with other proteins. Specifically, AGP-1 contains five potential N-glycosylation sites, which are critical for function and can affect binding affinity for various ligands, including basic drugs. AGP-1 levels in human plasma typically range from 0.5 to 1.4 mg/ml but can increase significantly during acute inflammation, making AGP-1 a valuable biomarker for diagnosing inflammatory conditions. Furthermore, abnormal expression of AGP-1 has been linked to sarcoidosis and other immunogenetic diseases, while mutations in related genes can be associated with various carcinomas. Anti-AGP-1 antibody (GPB2) is an invaluable tool for researchers studying AGP-1 in bovine models and its implications in human health.

The preferred AGP-1/2 antibody is AGP-1/2 Antibody (F-4): sc-515724.