Molecular structure of AGN 193109 Sodium Salt
AGN 193109 Sodium Salt (CAS 171746-21-7)
See product citations (33)
Alternate Names:
AGN 193109 Sodium Salt is also known as 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid Sodium Salt
Application:
AGN 193109 Sodium Salt is A retinoic acid receptor (RAR) antagonist that potently antagonizes against ATRA-induced transcription in RARα, RARβ, and RARγ transfected CV-1 cells
CAS Number:
171746-21-7
Purity:
≥95%
Molecular Weight:
414.47
Molecular Formula:
C28H23NaO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AGN 193109 Sodium Salt is a retinoic acid receptor (RAR) antagonist. AGN 193109 Sodium Salt targets all three RAR subtypes with higher affinity than all-trans retinoic acid/ATRA. In vitro studies have been conducted to investigate the interaction of AGN 193109 Sodium Salt with diverse proteins and receptors.
AGN 193109 Sodium Salt (CAS 171746-21-7) References
- Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes. | Thacher, SM., et al. 1999. Cell Growth Differ. 10: 255-62. PMID: 10319995
- All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells. | Purton, LE., et al. 2000. Blood. 95: 470-7. PMID: 10627451
- The synthetic retinoid AGN 193109 but not retinoic acid elevates CYP1A1 levels in mouse embryos and Hepa-1c1c7 cells. | Soprano, DR., et al. 2001. Toxicol Appl Pharmacol. 174: 153-9. PMID: 11446831
- Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents. | Standeven, AM., et al. 2001. Biochem Pharmacol. 62: 1501-9. PMID: 11728386
- 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes. | Nelson, AM., et al. 2006. J Invest Dermatol. 126: 2178-89. PMID: 16575387
- 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. | Griffin, JN., et al. 2010. Neurosci Res. 68: 185-90. PMID: 20708044
- Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. | Rogers, MA., et al. 2020. Arterioscler Thromb Vasc Biol. 40: 656-669. PMID: 31852220
- p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. | Li, Q., et al. 2020. Cell Rep. 30: 465-480.e6. PMID: 31940490
- Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells? | Latta, L., et al. 2021. Biomolecules. 11: PMID: 34827649
- All-trans retinoic acid alters the expression of adipogenic genes during the differentiation of bovine intramuscular and subcutaneous adipocytes. | Chung, KY., et al. 2021. J Anim Sci Technol. 63: 1397-1410. PMID: 34957453
- Specific antagonist of retinoid toxicity in mice. | Standeven, AM., et al. 1996. Toxicol Appl Pharmacol. 138: 169-75. PMID: 8658506
- Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors. | Standeven, AM., et al. 1996. Fundam Appl Toxicol. 33: 264-71. PMID: 8921345
- Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation. | Thacher, SM., et al. 1997. J Pharmacol Exp Ther. 282: 528-34. PMID: 9262312
Inhibitor of:
RAR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AGN 193109 Sodium Salt, 1 mg | sc-210768 | 1 mg | $362.00 | |||
AGN 193109 Sodium Salt, 10 mg | sc-210768A | 10 mg | $2507.00 |