Afloqualone (CAS 56287-74-2)
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Afloqualone is a synthetic quinazoline-based compound. Studies have demonstrated its anticonvulsant, anxiolytic, and anti-inflammatory properties. Animal models have shown reduced severity of depression and anxiety in response to Afloqualone treatment. In vitro investigations have focused on elucidating the mechanism of action of Afloqualone. These studies have provided evidence of its binding to the GABA-A receptor, resulting in the modulation of receptor activity. Furthermore, Afloqualone has been observed to reduce the production of pro-inflammatory cytokines, further supporting its anti-inflammatory effects. In addition, it exhibits inhibitory properties against the growth of cancer cells. Although the exact mechanism of action for Afloqualone remains unclear, it is believed to modulate the activity of the GABA-A receptor, which plays a role in regulating neural excitability. Additionally, Afloqualone has been found to possess anti-inflammatory properties, reducing the production of pro-inflammatory cytokines. Furthermore, it demonstrates inhibitory effects on cancer cell growth.
Afloqualone (CAS 56287-74-2) References
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- Accidental afloqualone intoxication in two dogs. | Ahn, JO., et al. 2018. J Vet Med Sci. 80: 152-155. PMID: 29142147
- UV-A induced DNA nicking activities of skin photosensitive drugs: phenothiazines, benzothiadiazines and afloqualone. | Fujita, H. and Matsuo, I. 1988. Chem Biol Interact. 66: 27-36. PMID: 3383286
- Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. | Ochiai, T. and Ishida, R. 1982. Jpn J Pharmacol. 32: 427-38. PMID: 7109348
- [General pharmacology of 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. I. Effects on the central nervous system (author's transl)]. | Ochiai, T., et al. 1981. Nihon Yakurigaku Zasshi. 78: 347-57. PMID: 7327455
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- Afloqualone photosensitivity: immunogenicity of afloqualone-photomodified epidermal cells. | Tokura, Y., et al. 1994. Photochem Photobiol. 60: 262-7. PMID: 7972379
- Photoleukomelanodermatitis (Kobori) induced by afloqualone. | Ishikawa, T., et al. 1994. J Dermatol. 21: 430-3. PMID: 8064007
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Afloqualone, 100 mg | sc-481648 | 100 mg | $84.00 |