Adipsin Antibody (D-3): sc-373860
- Adipsin Antibody (D-3) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 79-113 within an internal region of Adipsin of mouse origin
- recommended for detection of Adipsin of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for Adipsin Antibody (D-3) for WB applications. This reagent is now offered in a bundle with Adipsin Antibody (D-3) (see ordering information below).
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Adipsin Antibody (D-3) is a mouse monoclonal IgG3 antibody that detects Adipsin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Adipsin, also known as complement Factor D, plays a crucial role in the complement system, which is essential for immune response and inflammation regulation. This serine protease is primarily secreted by adipose tissue, where Adipsin is involved in the cleavage of complement factor B when complexed with activated complement component C3, thereby contributing to the activation of the alternative pathway of complement activation. The significance of Adipsin extends beyond enzymatic function; anti-Adipsin antibody (D-3) has revealed lower Adipsin levels in obese mice with hypothalamic defects. While this inverse correlation between Adipsin expression and obesity has been established in rodent models, similar findings in humans remain to be fully elucidated. Adipsin (D-3) antibody provides a valuable tool for researchers investigating Adipsin′s role in metabolic disorders and immune responses, facilitating a deeper understanding of biological significance.
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Adipsin Antibody (D-3) References:
- Mesangial immune complex glomerulonephritis due to complement factor D deficiency. | Abrera-Abeleda, MA., et al. 2007. Kidney Int. 71: 1142-7. PMID: 17410102
- Elevation of adipsin, a complement activating factor, in the mouse placenta during spontaneous abortion. | TAKESHITA, A., et al. 2010. J Reprod Dev. 56: 508-14. PMID: 20581430
- Complement factor D in age-related macular degeneration. | Stanton, CM., et al. 2011. Invest Ophthalmol Vis Sci. 52: 8828-34. PMID: 22003108
- Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus): Molecular and functional characterization and immune responsive mRNA expression analysis. | Godahewa, GI., et al. 2016. Fish Shellfish Immunol. 55: 423-33. PMID: 27311435
- Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors. | Yang, CY., et al. 2016. ACS Med Chem Lett. 7: 1092-1096. PMID: 27994744
- Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models. | Crowley, MA., et al. 2018. Invest Ophthalmol Vis Sci. 59: 940-951. PMID: 29450541
- Metabolism of complement factor D in renal failure. | Pascual, M., et al. 1988. Kidney Int. 34: 529-36. PMID: 3199673
- Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. | Zhang, W., et al. 2022. Bioorg Med Chem. 74: 117034. PMID: 36272185
- Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion. | Ma, L., et al. 2024. JCI Insight. 9: PMID: 38713526
- Adsorption of complement factor D by polyacrylonitrile dialysis membranes. | Pascual, M. and Schifferli, JA. 1993. Kidney Int. 43: 903-11. PMID: 8479128
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adipsin Antibody (D-3) | sc-373860 | 200 µg/ml | $316.00 | |||
Adipsin Antibody (D-3): m-IgG3 BP-HRP Bundle | sc-550443 | 200 µg Ab; 40 µg BP | $354.00 | |||
Adipsin (D-3) Neutralizing Peptide | sc-373860 P | 100 µg/0.5 ml | $68.00 |