AC-93253 iodide (CAS 108527-83-9)
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AC-93253 iodide is a synthetic small molecule that acts primarily as a potent and selective inhibitor of the bromodomain and extra-terminal (BET) family of proteins, which play a critical role in regulating gene expression by modulating the structure of chromatin. This inhibition is achieved through the competitive binding to the acetyl-lysine recognition motifs in the BET proteins, disrupting their interaction with chromatin. This disruption leads to alterations in the expression of genes involved in cell proliferation, apoptosis, and differentiation, which are critical processes in cellular biology and disease pathogenesis. As such, AC-93253 iodide is widely utilized in research studies aimed at elucidating the mechanisms of epigenetic regulation of gene expression and exploring the potential of BET inhibitors as a strategy for modulating gene expression in various diseases. Its role in research extends to studies on where epigenetic regulation plays a key role in pathology progression.
AC-93253 iodide (CAS 108527-83-9) References
- Identification of novel subtype selective RAR agonists. | Piu, F., et al. 2005. Biochem Pharmacol. 71: 156-62. PMID: 16303118
- Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity. | Zhang, Y., et al. 2009. Biochem Biophys Res Commun. 386: 729-33. PMID: 19559674
- The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. | Dan, L., et al. 2012. Haematologica. 97: 551-9. PMID: 22207684
- Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins. | Botta, G., et al. 2012. Curr Med Chem. 19: 5871-84. PMID: 22998567
- Rejuvenating sirtuins: the rise of a new family of cancer drug targets. | Bruzzone, S., et al. 2013. Curr Pharm Des. 19: 614-23. PMID: 23016857
- Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. | Sunami, Y., et al. 2013. PLoS One. 8: e57633. PMID: 23460888
- Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. | Blackford, JA., et al. 2014. Mol Endocrinol. 28: 1194-206. PMID: 24850414
- AC-93253 triggers the downregulation of melanoma progression markers and the inhibition of melanoma cell proliferation. | Karwaciak, I., et al. 2015. Chem Biol Interact. 236: 9-18. PMID: 25912555
- Development of a fluorescence resonance energy transfer-based intracellular assay to identify novel enterovirus 71 antivirals. | Lu, WW., et al. 2017. Arch Virol. 162: 713-720. PMID: 27873071
- Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, 'selectivity pocket' and NAD+-binding site. | Mellini, P., et al. 2017. Chem Sci. 8: 6400-6408. PMID: 28989670
- AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways. | Lai, YH., et al. 2017. J Hematol Oncol. 10: 172. PMID: 29132432
- LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. | Morishima, T., et al. 2019. Blood. 134: 1159-1175. PMID: 31366618
- The Orphan Nuclear Receptor TLX Is a Receptor for Synthetic and Natural Retinoids. | Griffett, K., et al. 2020. Cell Chem Biol. 27: 1272-1284.e4. PMID: 32763139
- NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells. | Xu, Y., et al. 2021. Stem Cell Res Ther. 12: 112. PMID: 33546767
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AC-93253 iodide, 10 mg | sc-257044 | 10 mg | $171.00 | |||
AC-93253 iodide, 50 mg | sc-257044A | 50 mg | $681.00 |