Molecular structure of AC-41848, CAS Number: 400856-69-1
AC-41848 (CAS 400856-69-1)
Alternate Names:
1-[(2,4-Dichlorophenyl)methyl]-6,7,8,9-tetrahydro-3-phenyl-5H-imidazo[1,2-a]azepinium bromide
Application:
AC-41848 is an extremely potent, cell permeable, subtype selective RAR (retinoic acid receptor) agonist
CAS Number:
400856-69-1
Purity:
≥98%
Molecular Weight:
452.21
Molecular Formula:
C21H21BrCl2N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
A potent, cell permeable, subtype selective retinoic acid receptor RAR agonist. AC-41848 has high selectivity (92%) for RAR . EC50 = 5.9 µM.
AC-41848 (CAS 400856-69-1) References
- Retinoids accelerate B lineage lymphoid differentiation. | Chen, X., et al. 2008. J Immunol. 180: 138-45. PMID: 18097013
- Retinoids stimulate periosteal bone resorption by enhancing the protein RANKL, a response inhibited by monomeric glucocorticoid receptor. | Conaway, HH., et al. 2011. J Biol Chem. 286: 31425-36. PMID: 21715325
- Retinoid receptors and therapeutic applications of RAR/RXR modulators. | le Maire, A., et al. 2012. Curr Top Med Chem. 12: 505-27. PMID: 22242853
- Csn3 gene is regulated by all-trans retinoic acid during neural differentiation in mouse P19 cells. | Komori, R., et al. 2013. PLoS One. 8: e61938. PMID: 23613978
- Tal2 expression is induced by all-trans retinoic acid in P19 cells prior to acquisition of neural fate. | Kobayashi, T., et al. 2014. Sci Rep. 4: 4935. PMID: 24816818
- Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR. | Li, X., et al. 2018. Biochim Biophys Acta Mol Cell Res. 1865: 605-615. PMID: 29326073
Activator of:
RAR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AC-41848, 5 mg | sc-252347 | 5 mg | $107.00 |