Molecular structure of A 841720, CAS Number: 869802-58-4
A 841720 (CAS 869802-58-4)
Alternate Names:
9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Application:
A 841720 is a potent & non-competitive mGluR-1 antagonist
CAS Number:
869802-58-4
Purity:
≥98%
Molecular Weight:
343.45
Molecular Formula:
C17H21N5OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A 841720 is a potent inhibitor of a specific enzyme involved in the regulation of cellular processes. It is used to study the function of this enzyme and its role in various cellular pathways. A 841720 is effectively block the activity of the enzyme. A 841720 is used to learn more about the molecular mechanisms underlying various cellular processes. Its ability to target this enzyme makes it important in the field of biochemistry and molecular biology.
A 841720 (CAS 869802-58-4) References
- Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. | El-Kouhen, O., et al. 2006. Br J Pharmacol. 149: 761-74. PMID: 17016515
- Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. | Morè, L., et al. 2007. Behav Pharmacol. 18: 273-81. PMID: 17551319
- Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. | Zhu, CZ., et al. 2008. Eur J Pharmacol. 580: 314-21. PMID: 18054908
- Allosteric modulators for mGlu receptors. | Gasparini, F. and Spooren, W. 2007. Curr Neuropharmacol. 5: 187-94. PMID: 19305801
- Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain. | Picker, MJ., et al. 2011. Behav Pharmacol. 22: 785-93. PMID: 21971021
- Recent advances in the medicinal chemistry of the metabotropic glutamate receptor 1 (mGlu₁). | Owen, DR. 2011. ACS Chem Neurosci. 2: 394-401. PMID: 22860168
- N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. | Lovell, KM., et al. 2013. Bioorg Med Chem Lett. 23: 3713-8. PMID: 23727046
- Role of glutamate receptors in the dorsal reticular nucleus in formalin-induced secondary allodynia. | Ambriz-Tututi, M., et al. 2013. Eur J Neurosci. 38: 3008-17. PMID: 23869620
- Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade. | Halbout, B., et al. 2014. J Neurosci. 34: 1781-90. PMID: 24478360
- Recent updates on incubation of drug craving: a mini-review. | Li, X., et al. 2015. Addict Biol. 20: 872-6. PMID: 25440081
- Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications. | Caprioli, D., et al. 2018. Biol Psychiatry. 84: 180-192. PMID: 29102027
- Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors. | Pereira, V. and Goudet, C. 2018. Front Mol Neurosci. 11: 464. PMID: 30662395
- Recent Advances in the Modulation of Pain by the Metabotropic Glutamate Receptors. | Mazzitelli, M., et al. 2022. Cells. 11: PMID: 36010684
Inhibitor of:
mGluR-1, mGluR-1a, mGluR-1b, and mGluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 841720, 10 mg | sc-203792 | 10 mg | $175.00 | |||
A 841720, 50 mg | sc-203792A | 50 mg | $741.00 |