A-673 Cell Lysate: sc-2414

The A-673 cell lysate is derived from the A-673 cell line, a human cell line established from the muscle of a rhabdomyosarcoma, a type of malignant tumor associated with soft tissue and muscle origin. This lysate is essentially a suspension of the total cellular contents of the A-673 cells, including proteins, nucleic acids, lipids, and other metabolites, providing a snapshot of the cellular environment at the time of extraction. Such lysates are invaluable in research, particularly in the fields of cancer biology and genetic studies, as they allow for in-depth analysis of cellular components under various conditions. Researchers have utilized A-673 cell lysate extensively to investigate the unique pathways involved in the development and progression of rhabdomyosarcoma, helping to explain mechanisms of oncogenesis, cellular proliferation, and apoptosis in this tumor type. Additionally, this lysate has been used to study the response of rhabdomyosarcoma cells to various external stimuli, including pharmaceutical agents and environmental stressors, thereby contributing to a broader understanding of cellular dynamics and molecular biology without direct therapeutic implications. The A-673 cell lysate serves as a critical tool in the exploration of tumor biology, offering insights that are crucial for advancing scientific knowledge in oncological research.

A-673 Cell Lysate References:

1. TRAIL delivered by mesenchymal stromal/stem cells counteracts tumor development in orthotopic Ewing sarcoma models.  |  Guiho, R., et al. 2016. Int J Cancer. 139: 2802-2811. PMID: 27558972
2. Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities.  |  Radic-Sarikas, B., et al. 2017. Mol Cancer Ther. 16: 88-101. PMID: 28062706
3. Production and characterization of monoclonal antibodies against recombinant extracellular domain of CD99.  |  Thangaretnam, KP., et al. 2019. Hum Antibodies. 27: 69-83. PMID: 30282350