Molecular structure of 9-Acridinecarboxylic acid, CAS Number: 5336-90-3
9-Acridinecarboxylic acid (CAS 5336-90-3)
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Alternate Names:
acridine-9-carboxylic acid
Application:
9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides
CAS Number:
5336-90-3
Purity:
≥96%
Molecular Weight:
223.23
Molecular Formula:
C14H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
9-Acridinecarboxylic acid hydrate functions as a fluorescent dye in molecular biology and cell biology. It is used to stain nucleic acids, particularly DNA, in order to visualize and study their structure and localization within cells. The mechanism of action of 9-Acridinecarboxylic acid hydrate involves intercalating between the base pairs of DNA, leading to the emission of fluorescence when exposed to ultraviolet light. This make it useful in tracking the movement and distribution of DNA in various cellular processes, such as replication, transcription, and repair. 9-Acridinecarboxylic acid hydrate can be utilized in assays to quantify DNA content and assess cell viability.
9-Acridinecarboxylic acid (CAS 5336-90-3) References
- Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration. | Gottikh, MB., et al. 1999. Nucleosides Nucleotides. 18: 1645-6. PMID: 10474239
- Chemiluminescent determination of hydrogen peroxide with 9-acridinecarbonylimidazole and use in measurement of glucose oxidase and alkaline phosphatase activity. | Waldrop, AA., et al. 2000. Luminescence. 15: 169-82. PMID: 10862146
- High stability and high efficiency chemiluminescent acridinium compounds obtained from 9-acridine carboxylic esters of hydroxamic and sulphohydroxamic acids. | Renotte, R., et al. 2000. Luminescence. 15: 311-20. PMID: 11038489
- DNA variability in five crystal structures of d(CGCAATTGCG). | Valls, N., et al. 2004. Acta Crystallogr D Biol Crystallogr. 60: 680-5. PMID: 15039556
- Synthesis, structures, and magnetic properties of the copper(II), cobalt(II), and manganese(II) complexes with 9-acridinecarboxylate and 4-quinolinecarboxylate ligands. | Bu, XH., et al. 2005. Inorg Chem. 44: 9837-46. PMID: 16363854
- New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease. | Chufarova, N., et al. 2018. Arch Pharm (Weinheim). 351: e1800050. PMID: 29870588
- Photochemistry of 9-acridinecarboxaldehyde in aqueous media. | Palm, WU. 2018. Photochem Photobiol Sci. 17: 964-974. PMID: 29915836
- Novel Cyclopentaquinoline and Acridine Analogs as Multifunctional, Potent Drug Candidates in Alzheimer's Disease. | Maciejewska, K., et al. 2022. Int J Mol Sci. 23: PMID: 35682556
- A Facile Route for the Preparation of 9-Acridinecarboxamide Derivatives | Alain Kossanyi, et al. 1999. An International Journal for Rapid Communication of Synthetic Organic Chemistry. 29(24): 4341-4346.
- Sensitized photolysis of diphenyliodonium cation through intra-ion-pair electron transfer-A novel near-UV photoinitiator: Diphenyliodonium 9-acridinecarboxylate | and Jun-Hui He, Jing-Chun Zhang. 1999. Journal of Polymer Science Part A: Polymer Chemistry. 37(24): 4521-4527.
- Pinhole-Containing, Subnanometer-Thick Al2O3 Shell-Coated Ag Nanorods as Practical Substrates for Quantitative Surface-Enhanced Raman Scattering | Lingwei Ma†, Yu Huang†, Mengjing Hou†, Jianghao Li†, Zheng Xie§, and Zhengjun Zhang*‡. 2016. J. Phys. Chem. C. 120(1): 606–615.
- Synthesis of new acridine-9-carboxylic acid derivatives | V. V. Melyshenkova, D. N. Kuznetsov, A. G. Ruchkina & K. I. Kobrakov. 2018. Russian Chemical Bulletin. 67: 878–883.
- Ultrafast spectroscopic studies of the pH responsive 9-acridinecarboxylic acid as a ratiometric and fluorescence lifetime pH indicator | Zhou, H., Zhao, Y., Chen, X., & Zhang, S. 2022. Microchemical Journal. 176: 107240.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9-Acridinecarboxylic acid, 1 g | sc-227136 | 1 g | $65.00 |