Date published: 2026-6-10

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8-M-PDOT (CAS 134865-70-6)

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Alternate Names:
8-Methoxy-2-propionamidotetralin
Application:
8-M-PDOT is a melatonin receptor agonist selective for MEL-1B-R subtype
CAS Number:
134865-70-6
Molecular Weight:
233.31
Molecular Formula:
C14H19NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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8-M-PDOT is a research compound primarily utilized in the study of circadian rhythms and sleep regulation. In laboratory applications, it is applied to investigate the functioning of melatonin receptors, as it exhibits high affinity and selectivity towards the MT2 melatonin receptor subtype. By binding to these receptors, 8-M-PDOT allows researchers to elucidate the signaling pathways and physiological roles that melatonin receptors play in the regulation of circadian rhythms. Neuroscientists use this compound to understand how modulation of these receptors affects sleep patterns, providing insights into the potential mechanisms of sleep disorders. Additionally, due to its specificity, 8-M-PDOT is useful in receptor mapping, helping to identify the distribution of MT2 receptors in various tissues.


8-M-PDOT (CAS 134865-70-6) References

  1. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors.  |  Browning, C., et al. 2000. Br J Pharmacol. 129: 877-86. PMID: 10696085
  2. Melatonin as an effective protector against doxorubicin-induced cardiotoxicity.  |  Liu, X., et al. 2002. Am J Physiol Heart Circ Physiol. 283: H254-63. PMID: 12063298
  3. Protective effect of melatonin on myocardial infarction.  |  Chen, Z., et al. 2003. Am J Physiol Heart Circ Physiol. 284: H1618-24. PMID: 12679327
  4. Melatonin-enhanced hyperactivation of hamster sperm.  |  Fujinoki, M. 2008. Reproduction. 136: 533-41. PMID: 18715981
  5. Circadian clocks in crustaceans: identified neuronal and cellular systems.  |  Strauss, J. and Dircksen, H. 2010. Front Biosci (Landmark Ed). 15: 1040-74. PMID: 20515741
  6. Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives.  |  Bedini, A., et al. 2011. J Med Chem. 54: 8362-72. PMID: 22047556
  7. Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells.  |  Dragicevic, N., et al. 2012. Neuropharmacology. 63: 1368-79. PMID: 22959965
  8. Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade.  |  Noseda, AC., et al. 2014. Behav Brain Res. 275: 136-45. PMID: 25218873
  9. New evidence of melatonin receptor contribution to ram sperm functionality.  |  Gonzalez-Arto, M., et al. 2016. Reprod Fertil Dev. 28: 924-935. PMID: 25515626
  10. Melatonin Suppresses Neuropathic Pain via MT2-Dependent and -Independent Pathways in Dorsal Root Ganglia Neurons of Mice.  |  Lin, JJ., et al. 2017. Theranostics. 7: 2015-2032. PMID: 28656058
  11. Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics.  |  Pariente, R., et al. 2017. Cancer Chemother Pharmacol. 80: 985-998. PMID: 28956121
  12. Melatonin receptors: are there multiple subtypes?  |  Dubocovich, ML. 1995. Trends Pharmacol Sci. 16: 50-6. PMID: 7762083
  13. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.  |  Dubocovich, ML., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 355: 365-75. PMID: 9089668

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-M-PDOT, 10 mg

sc-361091
10 mg
$138.00

8-M-PDOT, 50 mg

sc-361091A
50 mg
$570.00