Molecular structure of 8-Chloro-2′-deoxyadenosine, CAS Number: 85562-55-6
8-Chloro-2′-deoxyadenosine (CAS 85562-55-6)
CAS Number:
85562-55-6
Molecular Weight:
285.69
Molecular Formula:
C10H12ClN5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
8-Chloro-2′-deoxyadenosine is a modified nucleoside naturally present in DNA and RNA strands, and it serves as a valuable resource in numerous scientific research applications. Particularly beneficial to researchers in biochemistry, physiology, and genetics, it enables the manipulation and modification of genetic material to investigate various processes. This compound has demonstrated an ability to bind to the minor groove of DNA and establish a covalent bond with the DNA strand′s phosphodiester backbone. This covalent interaction can result in the inhibition of transcriptional activity and the induction of DNA strand breaks.
8-Chloro-2′-deoxyadenosine (CAS 85562-55-6) References
- 8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog. | Fujikawa, K., et al. 2002. FEBS Lett. 512: 149-51. PMID: 11852070
- Effects of 8-chlorodeoxyadenosine on DNA synthesis by the Klenow fragment of DNA polymerase I. | Chen, LS., et al. 2003. Bioorg Med Chem Lett. 13: 1509-12. PMID: 12699743
- Chemical basis of inflammation-induced carcinogenesis. | Ohshima, H., et al. 2003. Arch Biochem Biophys. 417: 3-11. PMID: 12921773
- Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. | Fukushima, S., et al. 2005. Carcinogenesis. 26: 1835-45. PMID: 15975961
- Detection of chlorinated DNA and RNA nucleosides by HPLC coupled to tandem mass spectrometry as potential biomarkers of inflammation. | Badouard, C., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 827: 26-31. PMID: 16260376
- Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents. | Stanley, NR., et al. 2010. Chem Res Toxicol. 23: 1293-302. PMID: 20593802
- Miscoding properties of 8-chloro-2'-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases. | Sassa, A., et al. 2013. Mutagenesis. 28: 81-8. PMID: 23076070
- Oxidative stress in the carcinogenicity of chemical carcinogens. | Kakehashi, A., et al. 2013. Cancers (Basel). 5: 1332-54. PMID: 24202448
- Hypobromous acid, a powerful endogenous electrophile: Experimental and theoretical studies. | Ximenes, VF., et al. 2015. J Inorg Biochem. 146: 61-8. PMID: 25771434
- Taurine Bromamine: Reactivity of an Endogenous and Exogenous Anti-Inflammatory and Antimicrobial Amino Acid Derivative. | De Carvalho Bertozo, L., et al. 2016. Biomolecules. 6: PMID: 27110829
- 8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response. | Tang, V., et al. 2019. Redox Biol. 26: 101274. PMID: 31307008
- 8-Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and DNA Damage Repair Pathways in Macrophages. | Macer-Wright, JL., et al. 2020. Chem Res Toxicol. 33: 402-413. PMID: 31778309
- Adenosine analogues as antimetabolites against Plasmodium falciparum malaria. | Coomber, DW., et al. 1994. Int J Parasitol. 24: 357-65. PMID: 8070953
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Chloro-2′-deoxyadenosine, 1 mg | sc-284836 | 1 mg | $153.00 | |||
8-Chloro-2′-deoxyadenosine, 5 mg | sc-284836A | 5 mg | $979.00 |