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7-Methyladenine (CAS 935-69-3)

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Alternate Names:
6-Amino-7-methylpurine; 7-Methyl-7H-purin-6-amine
CAS Number:
935-69-3
Molecular Weight:
149.15
Molecular Formula:
C6H7N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-Methyladenine is a methylated derivative of adenine, one of the four nucleobase components of nucleic acids, which plays a significant role in various biological processes, particularly in the realm of genetic expression and regulation. This chemical modification involves the addition of a methyl group at the 7th position of the adenine base, a subtle change that can have profound effects on its biological interactions and functionalities. In research applications, 7-Methyladenine is often explored for its potential to influence DNA and RNA′s structure and stability, thereby affecting the processes of replication, transcription, and translation. Its role in epigenetics is of particular interest, where it may impact gene expression by modulating the accessibility of DNA to transcription factors and other regulatory proteins. Additionally, 7-Methyladenine serves as a tool in the study of nucleic acid-protein interactions, providing insights into the mechanisms of action of various nucleic acid modifying enzymes and their roles in cellular processes.


7-Methyladenine (CAS 935-69-3) References

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  2. Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.  |  von Kügelgen, I., et al. 2008. Mol Pharmacol. 73: 469-77. PMID: 17975009
  3. Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of Sprague-Dawley rats.  |  Tokuda, S., et al. 2012. Biosci Biotechnol Biochem. 76: 828-30. PMID: 22484931
  4. Biomarkers of cigarette smoking and DNA methylating agents: Raman, SERS and DFT study of 3-methyladenine and 7-methyladenine.  |  Harroun, SG., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 176: 1-7. PMID: 28061366
  5. Cryogenic Ion Spectroscopy of Protonated and Sodiated Methyladenine Derivatives.  |  Eun, HJ., et al. 2023. J Phys Chem A. 127: 2472-2480. PMID: 36895090
  6. Partial purification and characterization of a human 3-methyladenine-DNA glycosylase.  |  Brent, TP. 1979. Biochemistry. 18: 911-6. PMID: 420822
  7. Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels.  |  Lawley, PD. and Shah, SA. 1972. Biochem J. 128: 117-32. PMID: 4673570
  8. The excision of N-methyl-N-nitrosourea-induced lesions from the DNA of Chinese hamster cells as measured by the loss of sites sensitive to an enzyme extract that excises 3-methylpurines but not O6-methylguanine.  |  Shackleton, J., et al. 1979. Eur J Biochem. 97: 425-33. PMID: 467426
  9. Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine.  |  Thomas, L., et al. 1982. Biochemistry. 21: 1162-9. PMID: 7041972
  10. Removal of minor methylation products 7-methyladenine and 3-methylguanine from DNA of Escherichia coli treated with dimethyl sulphate.  |  Lawley, PD. and Warren, W. 1976. Chem Biol Interact. 12: 211-20. PMID: 764991
  11. The excretion of 7-methyladenine in the urine of rats exposed to carcinogenic methylating agents.  |  Mandel, HG., et al. 1994. Carcinogenesis. 15: 1393-8. PMID: 8033316
  12. Quantitation of urinary 7-methyladenine by gas chromatography-mass spectrometry using isotopically labeled internal standards.  |  Mandel, HG., et al. 1994. Anal Biochem. 217: 292-7. PMID: 8203758
  13. Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine.  |  Margison, GP., et al. 1976. Biochem J. 157: 627-34. PMID: 985411

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-Methyladenine, 100 mg

sc-233690
100 mg
$176.00