7-Hydroxyindole (CAS 2380-84-9)
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7-Hydroxyindole (7-HI) is a compound that occurs naturally in both plants and animals. Derived from indole, an aromatic compound found in various plant and animal products, 7-Hydroxyindole holds significant importance as an intermediate in the synthesis of numerous compounds. The mechanism of action of 7-Hydroxyindole involves its interaction with specific receptors. It is believed to act as an agonist of the serotonin receptor 5-HT2A. Additionally, 7-Hydroxyindole is thought to act as an antagonist of the dopamine receptor D2, which contributes to the control of movement and reward-seeking behavior. Furthermore, it is believed to act as an agonist of the melatonin receptor MT1, involved in regulating sleep-wake cycles.
7-Hydroxyindole (CAS 2380-84-9) References
- Microbial hydroxylation of indole to 7-hydroxyindole by Acinetobacter calcoaceticus strain 4-1-5. | Sugimori, D., et al. 2004. Biosci Biotechnol Biochem. 68: 1167-9. PMID: 15170130
- Multicomponent phenol hydroxylase-catalysed formation of hydroxyindoles and dyestuffs from indole and its derivatives. | Kim, JY., et al. 2005. Lett Appl Microbiol. 41: 163-8. PMID: 16033515
- Enterohemorrhagic Escherichia coli biofilms are inhibited by 7-hydroxyindole and stimulated by isatin. | Lee, J., et al. 2007. Appl Environ Microbiol. 73: 4100-9. PMID: 17483266
- Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase. | Yamazaki, Y. and Kawano, Y. 2010. Z Naturforsch C J Biosci. 65: 49-54. PMID: 20355321
- Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence. | Lee, J., et al. 2009. Microb Biotechnol. 2: 75-90. PMID: 21261883
- A microfluidic device for high throughput bacterial biofilm studies. | Kim, J., et al. 2012. Lab Chip. 12: 1157-63. PMID: 22318368
- A procedure for transforming indoles into indolequinones. | Eastabrook, AS., et al. 2015. J Org Chem. 80: 1006-17. PMID: 25525818
- Rhodium-Catalyzed sp2 C-H Acetoxylation of N-Aryl Azaindoles/N-Heteroaryl Indolines. | Mishra, A., et al. 2017. J Org Chem. 82: 12406-12415. PMID: 29068203
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Hydroxyindole, 250 mg | sc-217454A | 250 mg | $49.00 | |||
7-Hydroxyindole, 1 g | sc-217454 | 1 g | $168.00 | |||
7-Hydroxyindole, 5 g | sc-217454B | 5 g | $658.00 | |||
7-Hydroxyindole, 25 g | sc-217454C | 25 g | $2519.00 |