Date published: 2026-1-20

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7-(β-Hydroxyethyl)-theophylline (CAS 519-37-9)

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Alternate Names:
Etofylline; 1,3-Dimethyl-7-(2-hydroxyethyl)xanthine
Application:
7-(β-Hydroxyethyl)-theophylline is a weak phosphodiesterase inhibitor & an intermediate for 7-substituted xanthine
CAS Number:
519-37-9
Purity:
≥95%
Molecular Weight:
224.22
Molecular Formula:
C9H12N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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7-(β-Hydroxyethyl)-theophylline is a compound that functions as a phosphodiesterase inhibitor. It acts by inhibiting the enzyme phosphodiesterase, which in turn leads to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. This increase in cAMP levels can result in various cellular responses, including smooth muscle relaxation, bronchodilation, and increased contractility of the heart muscle. 7-(β-Hydroxyethyl)-theophylline may have anti-inflammatory effects, which may be attributed to its ability to inhibit phosphodiesterase. At the molecular level, 7-(β-Hydroxyethyl)-theophylline interacts with the catalytic site of phosphodiesterase, preventing the hydrolysis of cAMP and thereby prolonging its intracellular effects. This mechanism of action makes 7-(β-Hydroxyethyl)-theophylline a for studying cellular signaling pathways and investigating the role of cAMP in various physiological processes.


7-(β-Hydroxyethyl)-theophylline (CAS 519-37-9) References

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  5. Synthesis of titania monoliths for chromatographic separations.  |  Randon, J., et al. 2008. J Chromatogr A. 1214: 183-6. PMID: 19010481
  6. Determination of the caffeine contents of various food items within the Austrian market and validation of a caffeine assessment tool (CAT).  |  Rudolph, E., et al. 2012. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 29: 1849-60. PMID: 22963537
  7. HPLC Method for Quantification of Caffeine and Its Three Major Metabolites in Human Plasma Using Fetal Bovine Serum Matrix to Evaluate Prenatal Drug Exposure.  |  Lopez-Sanchez, RDC., et al. 2018. J Anal Methods Chem. 2018: 2085059. PMID: 30186659
  8. Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host.  |  Efimova, SS., et al. 2020. Front Cell Dev Biol. 8: 537. PMID: 32695785

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

7-(β-Hydroxyethyl)-theophylline, 5 g

sc-202836
5 g
$42.00