Molecular structure of 6α-Hydroxyestradiol, CAS Number: 1229-24-9
6α-Hydroxyestradiol (CAS 1229-24-9)
Alternate Names:
1,3,5(10)-Estratriene-3,6α,17β-triol
CAS Number:
1229-24-9
Molecular Weight:
288.38
Molecular Formula:
C18H24O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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6α-Hydroxyestradiol is a metabolite of 17β-estradiol, and it is involved in the regulation of estrogen receptor activity. It acts as an agonist of the estrogen receptor, binding to the receptor and activating downstream signaling pathways. This activation leads to the modulation of gene expression, influencing cellular processes such as proliferation, differentiation, and apoptosis. 6α-Hydroxyestradiol also plays a role in the regulation of angiogenesis, contributing to the formation of new blood vessels. At the molecular level, it interacts with estrogen receptors α and β, influencing their transcriptional activity and ultimately affecting cellular function. 6α-Hydroxyestradiol may exhibit antioxidant properties, protecting cells from oxidative stress and DNA damage.
6α-Hydroxyestradiol (CAS 1229-24-9) References
- Synthesis of 6- and 7-hydroxyestradiol 17-sulfates: the potential metabolites of estradiol 17-sulfate by female rat liver microsomes. | Itoh, Y., et al. 1999. Steroids. 64: 363-70. PMID: 10406486
- Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism. | Jansson, I., et al. 2001. Pharmacogenetics. 11: 793-801. PMID: 11740343
- Stimulatory effect of cigarette smoking on the 15 alpha-hydroxylation of estradiol by human term placenta. | Zhu, BT., et al. 2002. Clin Pharmacol Ther. 71: 311-24. PMID: 12011817
- A possible alternative to 17beta-estradiol in a viviparous lizard, Tiliqua nigrolutea. | Edwards, A., et al. 2002. Gen Comp Endocrinol. 129: 114-21. PMID: 12441121
- A novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells. | Zheng, ZY., et al. 2005. J Biol Chem. 280: 17480-7. PMID: 15728178
- Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding. | Zhu, BT., et al. 2006. Endocrinology. 147: 4132-50. PMID: 16728493
- Mass spectrometric analysis of oxygenations in aromatization of androst-4-ene-3,6,17-trione, a suicide substrate of aromatase, by placental microsomes. Isotope effect and stereochemistry. | Numazawa, M., et al. 2007. J Steroid Biochem Mol Biol. 107: 220-7. PMID: 17651966
- Expression of human liver 3, 4-catechol estrogens UDP-Glucuronosyltransferase cDNA in COS 1 cells. | Ahn, MR., et al. 1997. Arch Pharm Res. 20: 465-70. PMID: 18982491
- A new reliable sample preparation for high throughput focused steroid profiling by gas chromatography-mass spectrometry. | Anizan, S., et al. 2010. J Chromatogr A. 1217: 6652-60. PMID: 20537338
- An efficient route to polysubstituted tetrahydronaphthols: silver-catalyzed [4+2] cyclization of 2-alkylbenzaldehydes and alkenes. | Zhu, S., et al. 2012. Angew Chem Int Ed Engl. 51: 10861-5. PMID: 23011915
- Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches. | Ciallella, HL., et al. 2021. Lab Invest. 101: 490-502. PMID: 32778734
- Hepatic sulfation of estrogen metabolites. | Brooks, SC. and Horn, L. 1971. Biochim Biophys Acta. 231: 233-41. PMID: 4323008
- Effect of dietary 2(3)-tert-butyl-4-hydroxyanisole on the metabolism and action of estradiol and estrone in female CD-1 mice. | Zhu, BT., et al. 1997. Cancer Res. 57: 2419-27. PMID: 9192820
- Diverse function of aromatase and the N-terminal sequence deleted form. | Osawa, Y., et al. 1997. J Steroid Biochem Mol Biol. 61: 117-26. PMID: 9365180
- Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. | Zhu, BT., et al. 1998. Carcinogenesis. 19: 1821-7. PMID: 9806165
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6α-Hydroxyestradiol, 2 mg | sc-233658 | 2 mg | $133.00 |