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6-O-Palmitoyl-L-ascorbic acid (CAS 137-66-6)

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Alternate Names:
L-Ascorbic acid 6-palmitate; L-Ascorbic acid 6-hexadecanoate
CAS Number:
137-66-6
Purity:
≥99%
Molecular Weight:
414.53
Molecular Formula:
C22H38O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-O-Palmitoyl-L-ascorbic acid, also known as ascorbyl palmitate, is used in biochemical research due to its antioxidant properties. In studies examining lipid oxidation, it is often utilized to understand the protective effects of antioxidants on cell membranes and lipoproteins. Researchers use 6-O-Palmitoyl-L-ascorbic acid to investigate its incorporation into lipid layers and its ability to scavenge free radicals, which contributes to the understanding of oxidative stress and its management in biological systems. Additionally, this compound is of interest in the study of food chemistry, where it is used to explore the stabilization of oils and fats against oxidation to improve shelf-life and nutritional value. In material science, 6-O-Palmitoyl-L-ascorbic acid′s amphiphilic nature makes it an interesting candidate for creating antioxidant-infused polymers and coatings.


6-O-Palmitoyl-L-ascorbic acid (CAS 137-66-6) References

  1. Michael adducts of palmitoylascorbic acid: effects on the oxidative burst of neutrophils and the production of tumor necrosis factor-alpha in monocytes.  |  Gütschow, M., et al. 2002. Pharmacology. 66: 162-8. PMID: 12372906
  2. Apoptosis by 6-O-palmitoyl-L-ascorbic acid coincides with JNK-phosphorylation and inhibition of Mg2+-dependent phosphatase activity.  |  Kaap, S., et al. 2004. Biochem Pharmacol. 67: 919-26. PMID: 15104245
  3. Kinetics and mechanism of the reaction between ascorbic acid derivatives and an arenediazonium salt: cationic micellar effects.  |  Costas-Costas, U., et al. 2005. Langmuir. 21: 10983-91. PMID: 16285762
  4. Anticancer effects of 6-o-palmitoyl-ascorbate combined with a capacitive-resistive electric transfer hyperthermic apparatus as compared with ascorbate in relation to ascorbyl radical generation.  |  Kato, S., et al. 2011. Cytotechnology. 63: 425-35. PMID: 21667158
  5. The influence of additives on the oxidation of pork back fat and its effect on water and fat binding in finely comminuted batters.  |  Bloukas, I. and Honikel, KO. 1992. Meat Sci. 32: 31-43. PMID: 22059721
  6. Alkyl esters of L-ascorbic acid: Stability, surface behaviour and interaction with phospholipid monolayers.  |  Mottola, M., et al. 2015. J Colloid Interface Sci. 457: 232-42. PMID: 26188730
  7. Amplification of resonance Rayleigh scattering of gold nanoparticles by tweaking into nanowires: Bio-sensing of α-tocopherol by enhanced resonance Rayleigh scattering of curcumin capped gold nanowires through non-covalent interaction.  |  El Kurdi, R. and Patra, D. 2017. Talanta. 168: 82-90. PMID: 28391869
  8. Problems and solutions of polyethylene glycol co-injection method in multiresidue pesticide analysis by gas chromatography-mass spectrometry: evaluation of instability phenomenon in type II pyrethroids and its suppression by novel analyte protectants.  |  Akutsu, K., et al. 2018. Anal Bioanal Chem. 410: 3145-3160. PMID: 29556739
  9. Effects of lipophilic derivatives of L-ascorbic acid and dehydro-L-ascorbic acid on the peroxidation of linoleic acid in neutral phosphate buffer containing alcohol.  |  Takagi, M., et al. 1986. J Nutr Sci Vitaminol (Tokyo). 32: 389-94. PMID: 3806253
  10. Synthesis of 6-O-palmitoyl L-ascorbic acid catalyzed by Candida antartica lipase  |  Humeau C., Girardin M., Coulon D. & Miclo A.. 1995. Biotechnology Letters. 17: 1091–1094.
  11. High yields of ascorbyl palmitate by thermostable lipase-mediated esterification  |  S. Bradoo, R. K. Saxena & R. Gupta. 1999. Journal of the American Oil Chemists' Society. 76: 1291–1295.
  12. Lipase-catalyzed synthesis of 6-O-eicosapentaenoyl L-ascorbate in acetone and its autoxidation  |  Yoshiyuki Watanabe, Yasumasa Minemoto, Shuji Adachi, Kazuhiro Nakanishi, Yuji Shimada & Ryuichi Matsuno. 2000. Biotechnology Letters. 22: 637–640.
  13. An electrochemical sensor for trace uranium determination based on 6-O-palmitoyl-l-ascorbic acid-modified graphite electrodes  |  Panagiotis A. Dimovasilis, Mamas I. Prodromidis. 2011. Sensors and Actuators B: Chemical. 156: 689-694.
  14. Thermal frontal polymerization with a thermally released redox catalyst  |  Claudio Attardo Parrinello, Christopher O. Bounds, Maria Liria Turco Liveri, John A. Pojman. 2012. Journal of Polymer Science Part A: Polymer Chemistry. 50: 2337-2343.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-O-Palmitoyl-L-ascorbic acid, 25 g

sc-239113
25 g
$43.00