Date published: 2025-12-5

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5β-Cholestan-3α-ol (CAS 516-92-7)

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Alternate Names:
Epicoprostanol
Application:
5β-Cholestan-3α-ol is a sterol produced endogenously from cholesterol
CAS Number:
516-92-7
Purity:
≥95%
Molecular Weight:
388.67
Molecular Formula:
C27H48O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5β-Cholestan-3α-ol, a chemical compound of interest in scientific research, has been extensively studied for its diverse mechanisms of action and potential applications. Researchers have investigated its role in various research fields, including biochemistry, lipid metabolism, and cell biology. One notable mechanism of action is its involvement in cholesterol homeostasis. Studies have explaind its impact on cellular cholesterol levels by modulating key enzymes and transporters involved in cholesterol synthesis, uptake, and efflux. Furthermore, 5β-Cholestan-3α-ol has been found to interact with nuclear receptors, such as liver X receptors (LXRs) and farnesoid X receptor (FXR), influencing gene expression related to cholesterol metabolism and bile acid synthesis. Additionally, this compound has been utilized in membrane research to investigate its effects on lipid bilayer properties and membrane fluidity. Its incorporation into model lipid membranes has provided insights into the impact of its structural features on membrane organization and functionality. Moreover, studies have explored its potential as a precursor for the synthesis of novel steroidal derivatives and analogs, facilitating the development of new compounds with tailored properties for various applications. The ongoing scientific investigations into the mechanisms and applications of 5β-Cholestan-3α-ol continue to expand our understanding of its role in cellular processes and offer opportunities for further advancements in diverse research fields.


5β-Cholestan-3α-ol (CAS 516-92-7) References

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  2. Sterol stringency of proliferation and cell cycle progression in human cells.  |  Suárez, Y., et al. 2005. Biochim Biophys Acta. 1734: 203-13. PMID: 15904877
  3. Synthesis of monodispersed molecularly imprinted polymer particles for high-performance liquid chromatographic separation of cholesterol using templating polymerization in porous silica gel bound with cholesterol molecules on its surface.  |  Kitahara, K., et al. 2010. J Chromatogr A. 1217: 7249-54. PMID: 20934706
  4. Extreme variability of steroid profiles in cow feces and pig slurries at the regional scale: implications for the use of steroids to specify fecal pollution sources in waters.  |  Derrien, M., et al. 2011. J Agric Food Chem. 59: 7294-302. PMID: 21604805
  5. Origin of fecal contamination in waters from contrasted areas: stanols as Microbial Source Tracking markers.  |  Derrien, M., et al. 2012. Water Res. 46: 4009-16. PMID: 22673347
  6. Evaluation of potential sewage contamination by fecal sterol biomarkers adsorbed in natural biofilms.  |  Froehner, S. and Sánez, J. 2013. Environ Sci Process Impacts. 15: 2080-6. PMID: 24064988
  7. Seasonal variation of lipids in femoral gland secretions of male green iguanas (Iguana iguana).  |  Alberts, AC., et al. 1992. J Chem Ecol. 18: 703-12. PMID: 24253964
  8. Rapid measurement of phytosterols in fortified food using gas chromatography with flame ionization detection.  |  Duong, S., et al. 2016. Food Chem. 211: 570-6. PMID: 27283669
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  10. Side-chain oxidation of monooxygenated C27- and C29-steroids in rat liver mitochondria and 18000 x g supernatant.  |  Aringer, L. and Nordström, L. 1981. Biochim Biophys Acta. 665: 13-21. PMID: 7284411

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5β-Cholestan-3α-ol, 500 mg

sc-214350
500 mg
$772.00

5β-Cholestan-3α-ol, 1 g

sc-214350A
1 g
$1539.00