Date published: 2026-5-24

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5β-Cholanic acid (CAS 546-18-9)

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CAS Number:
546-18-9
Purity:
≥95%
Molecular Weight:
360.57
Molecular Formula:
C24H40O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5β-Cholanic acid, also known as 5β-cholanoic acid, is a naturally occurring bile acid in the human body. It is produced in the liver from cholesterol and secreted into the bile, contributing to the digestion and absorption of dietary fats and lipids. Apart from being present in the human body, 5β-Cholanic acid can also be found in certain foods like dairy products, eggs, and fish. This bile acid is frequently used in laboratory experiments as a representative bile acid due to its similar structure and function. It finds extensive use in molecular biology studies, as it plays a role in gene expression regulation. In lipid metabolism studies, it can be utilized to examine the impact of bile acids on cholesterol levels. 5β-Cholanic acid participates in numerous biochemical and physiological processes. Within the liver, it contributes to bile acid synthesis and cholesterol level regulation. In the gastrointestinal tract, it aids in the digestion and absorption of dietary fats and lipids, while in the kidneys, it assists in bile acid reabsorption and electrolyte level regulation.


5β-Cholanic acid (CAS 546-18-9) References

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  2. 5beta-Cholane activators of the farnesol X receptor.  |  Fukuchi, J., et al. 2005. J Steroid Biochem Mol Biol. 94: 311-8. PMID: 15857750
  3. The novel compounds that activate farnesoid X receptor: the diversity of their effects on gene expression.  |  Suzuki, T., et al. 2008. J Pharmacol Sci. 107: 285-94. PMID: 18603830
  4. Tumor targeting chitosan nanoparticles for dual-modality optical/MR cancer imaging.  |  Nam, T., et al. 2010. Bioconjug Chem. 21: 578-82. PMID: 20201550
  5. Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy.  |  Yoon, HY., et al. 2012. Biomaterials. 33: 3980-9. PMID: 22364699
  6. Self-assembling nanocomposites for protein delivery: supramolecular interactions between PEG-cholane and rh-G-CSF.  |  Salmaso, S., et al. 2012. J Control Release. 162: 176-84. PMID: 22727711
  7. Effect of the stability and deformability of self-assembled glycol chitosan nanoparticles on tumor-targeting efficiency.  |  Na, JH., et al. 2012. J Control Release. 163: 2-9. PMID: 22846988
  8. Steroids as γ-secretase modulators.  |  Jung, JI., et al. 2013. FASEB J. 27: 3775-85. PMID: 23716494
  9. Wittig reaction (with ethylidene triphenylphosphorane) of oxo-hydroxy derivatives of 5β-cholanic acid: Hydrophobicity, haemolytic potential and capacity of derived ethylidene derivatives for solubilisation of cholesterol.  |  Poša, M., et al. 2014. Steroids. 86: 16-25. PMID: 24819990
  10. Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis.  |  Heo, R., et al. 2017. Biomaterials. 131: 15-26. PMID: 28371624
  11. 5β-Cholanic Acid/Glycol Chitosan Self-Assembled Nanoparticles (5β-CHA/GC-NPs) for Enhancing the Absorption of FDs and Insulin by Rat Intestinal Membranes.  |  Yan, C., et al. 2019. AAPS PharmSciTech. 20: 30. PMID: 30603934
  12. Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding.  |  Vasiljević, BR., et al. 2021. RSC Med Chem. 12: 278-287. PMID: 34046616

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5β-Cholanic acid, 1 g

sc-214342
1 g
$338.00