Molecular structure of 5-trans Prostaglandin E2, CAS Number: 36150-00-2
5-trans Prostaglandin E2 (CAS 36150-00-2)
Alternate Names:
trans-Dinoprostone; 5,6-trans PGE2
Application:
5-trans Prostaglandin E2 is a PGE2 analog 18 times more potent than PGE2 in activation of adenylate cyclase in NCB-20 cells
CAS Number:
36150-00-2
Molecular Weight:
352.5
Molecular Formula:
C20H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-trans PGE2 is a naturally occuring compound and is a common impurity in commercial lots of PGE1, that shows a potency that is 18 times greater than PGE2 (5-cis PGE2) in cases of activation of adenylate cyclase in NCB-20 cell homogenates. Also has been shown to accelerate fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator, and to inhibit platelet aggregation in platelet rich plasma (PRP).
5-trans Prostaglandin E2 (CAS 36150-00-2) References
- trans-5-prostaglandin E2 stimulates plasminogen activation by tissue-type plasminogen activator. | Shimokawa, M., et al. 1992. Biochim Biophys Acta. 1137: 317-20. PMID: 1445933
- Trans-prostaglandin E2 enhances fibrinolysis. | Urano, T., et al. 1992. J Pharmacobiodyn. 15: 261-5. PMID: 1527702
- Integrated transcriptomics and metabolomics analyses to investigate the anticancer mechanisms of cinobufagin against liver cancer through interfering with lipid, amino acid, carbohydrate, and nucleotide metabolism. | Yang, A., et al. 2023. Bioorg Chem. 130: 106229. PMID: 36335648
- Proceedings: The effects of some prostaglandins on respiration in the rabbit. | Brookes, LG. and Marshall, RC. 1974. J Pharm Pharmacol. 26 Suppl: 80-81. PMID: 4156762
- Isolation of a new naturally occurring prostaglandin, 5-trans-PGA 2. Synthesis of 5-trans-PGE 2 and 5-trans-PGF 2a . | Bundy, GL., et al. 1972. J Am Chem Soc. 94: 2124. PMID: 4401384
- Structure-activity relationships of prostanoids that activate adenylate cyclase of neuronal hybrid cells [proceedings]. | Hensby, CN. and MacDermot, J. 1979. Biochem Soc Trans. 7: 1302-4. PMID: 535664
- Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: prostanoid structure-activity relationships. | Blair, IA., et al. 1980. Br J Pharmacol. 69: 519-25. PMID: 6249437
- Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. | Kobzar, G., et al. 1993. Comp Biochem Physiol C Comp Pharmacol Toxicol. 106: 489-94. PMID: 7904921
- Different effect of 5,6-trans-prostaglandin E2 on plasminogen activation by urokinase and streptokinase. | Urano, T., et al. 1994. Biochim Biophys Acta. 1205: 258-61. PMID: 8155706
- Determination of 5-trans-prostaglandin E2 in prostaglandin E2 via high performance liquid chromatography of their p-nitrophenacyl esters on a silver ion-loaded cation exchange resin. | Merritt, MV. and Bronson, GE. 1976. Anal Chem. 48: 1851-3. PMID: 970637
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-trans Prostaglandin E2, 1 mg | sc-205142 | 1 mg | $60.00 | |||
5-trans Prostaglandin E2, 5 mg | sc-205142A | 5 mg | $272.00 |