Date published: 2025-9-19

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5-Sulfosalicylic acid dihydrate (CAS 5965-83-3)

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Application:
5-Sulfosalicylic acid dihydrate is for reducing and fixation of proteins in agarose and polyacrylamide gels
CAS Number:
5965-83-3
Purity:
≥99%
Molecular Weight:
254.2
Molecular Formula:
C7H6O6S 2H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Sulfosalicylic acid dihydrate is a derivative of salicylic acid that includes a sulfonic acid group, enhancing its solubility and reactivity in water. This chemical is widely recognized for its role in various analytical chemistry applications, particularly due to its strong acid properties and ability to form complexes with proteins. In research settings, one of the primary uses of 5-sulfosalicylic acid dihydrate is in the qualitative determination of proteins in urine samples. The mechanism behind this application involves the acid′s ability to precipitate proteins, a reaction that is critical for assessing proteinuria in non-clinical research environments. Furthermore, due to its sulfonic acid group, 5-sulfosalicylic acid dihydrate acts as an excellent chelating agent, capable of binding with various metal ions. This ability is exploited in the synthesis of metal complexes in materials science, where it helps in the study of metal coordination compounds. The compound′s strong acidic nature also makes it useful as a catalyst in organic synthesis, promoting reactions such as esterification and hydrolysis by providing an acidic medium. These diverse applications underscore its utility in laboratories, aiding in both the analysis and synthesis of various chemical compounds in a non-medical context.


5-Sulfosalicylic acid dihydrate (CAS 5965-83-3) References

  1. Quantification of lanthanides in rocks using succinic acid-derivatized sorbents for on-line SPE-RP-ion-pair HPLC.  |  Buchmeiser, MR., et al. 2000. Anal Chem. 72: 2595-602. PMID: 10857641
  2. Salicylic acid derivatives form stable complexes with scandium(III) ion in aqueous solution.  |  Türkel, N. and Ozer, U. 2000. Chem Pharm Bull (Tokyo). 48: 870-2. PMID: 10866151
  3. Protonation and complex formation of 5-sulfosalicylate in NaCl, CaCl2 and MgCl2 aqueous media. Speciation in synthetic seawater.  |  Foti, C., et al. 2002. Ann Chim. 92: 551-62. PMID: 12125460
  4. Two salts of 5-sulfosalicylic acid and 3-aminopyridine.  |  Meng, XG., et al. 2007. Acta Crystallogr C. 63: o667-70. PMID: 17989492
  5. Proton transfer versus nontransfer in compounds of the diazo-dye precursor 4-(phenyldiazenyl)aniline (aniline yellow) with strong organic acids: the 5-sulfosalicylate and the dichroic benzenesulfonate salts, and the 1:2 adduct with 3,5-dinitrobenzoic acid.  |  Smith, G., et al. 2009. Acta Crystallogr C. 65: o543-8. PMID: 19805891
  6. 5-Sulfosalicylic acid dihydrate-based pretreatment for the modification of enzyme-linked immunoassay of fluoroquinolones in fishery products.  |  Cui, M., et al. 2015. J Immunoassay Immunochem. 36: 517-31. PMID: 25611486
  7. Ultrasensitive colorimetric assay of cadmium ion based on silver nanoparticles functionalized with 5-sulfosalicylic acid for wide practical applications.  |  Jin, W., et al. 2015. Analyst. 140: 3507-13. PMID: 25831211
  8. Rapid method for the separation and detection of tissue short-chain coenzyme A esters by reversed-phase high-performance liquid chromatography.  |  Demoz, A., et al. 1995. J Chromatogr B Biomed Appl. 667: 148-52. PMID: 7663677
  9. A sensitive and simple high-performance liquid chromatographic method for the determination of mitoxantrone in plasma.  |  Slørdal, L., et al. 1993. Ther Drug Monit. 15: 328-33. PMID: 8236369
  10. A method for myoglobin in cryostat sections of muscle by precipitation with sulfosalicylic acid.  |  Swatland, HJ. 1979. Stain Technol. 54: 245-9. PMID: 93325
  11. Controllable 5-sulfosalicylic acid assisted solvothermal synthesis of monodispersed superparamagnetic Fe3O4 nanoclusters with tunable size  |  Wentao Wang a, Bingtao Tang a, Suli Wu a, Zhanming Gao a, Benzhi Ju a, Xiaoxu Teng b, Shufen Zhang a. 2017. Journal of Magnetism and Magnetic Materials. 423: 111-117.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Sulfosalicylic acid dihydrate, 100 g

sc-202892
100 g
$53.00

5-Sulfosalicylic acid dihydrate, 500 g

sc-202892A
500 g
$81.00