5(S),14(R)-Lipoxin B4 (CAS 98049-69-5)

5(S),14(R)-Lipoxin B4, with the CAS number 98049-69-5, is a specialized lipid molecule classified as a lipoxin, which is part of the larger family of bioactive compounds known as eicosanoids. These molecules are derived from arachidonic acid, a polyunsaturated fatty acid that plays a critical role in the inflammatory response and cellular signaling. Lipoxin B4 specifically is characterized by its unique structural conformation and stereochemistry, which are crucial for its function. In research, 5(S),14(R)-Lipoxin B4 is extensively studied for its role in modulating inflammation through non-classical pathways. Unlike other pro-inflammatory mediators, lipoxins generally act to resolve inflammation and promote the return to homeostasis. This specific isomer of Lipoxin B4 interacts with distinct G-protein-coupled receptors on the surfaces of immune cells, leading to the suppression of chemotactic response and inhibition of the migration of leukocytes to sites of inflammation. Furthermore, it influences the cytokine secretion profile, shifting the balance towards anti-inflammatory and reparative processes. These actions make 5(S),14(R)-Lipoxin B4 a subject of interest in the study of the resolution phase of inflammation, providing insights into the mechanisms of inflammation resolution and the potential for modulating immune responses in pathological conditions without directly invoking immune suppression.