Molecular structure of 5-Fluoro Cytosine, CAS Number: 2022-85-7
5-Fluoro Cytosine (CAS 2022-85-7)
Alternate Names:
4-Amino-5-fluoro-2(1H)-pyrimidine
Application:
5-Fluoro Cytosine is a toxic antimicrobial and antifungal agent
CAS Number:
2022-85-7
Purity:
≥98%
Molecular Weight:
129.09
Molecular Formula:
C4H4FN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Fluoro Cytosine is a nucleoside analog with potent antifungal properties. This compound undergoes deamination by cytosine deaminase, leading to the formation of 5-fluorouracil. The presence of 5-Fluoro Cytosine in the system disrupts RNA function by inducing miscoding. Furthermore, 5-Fluoro Cytosine hampers the synthesis of DNA and RNA and interferes with the production of ribosomal proteins.
5-Fluoro Cytosine (CAS 2022-85-7) References
- Gas-chromatographic determination of 5-fluorocytosine in human serum. | Harding, SA., et al. 1976. Clin Chem. 22: 772-6. PMID: 1277460
- Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. | HEIDELBERGER, C., et al. 1957. Nature. 179: 663-6. PMID: 13418758
- Growth inhibition of a human tumor cell strain by 5-fluorocytidine and 5-fluoro-2'-deoxycytidine: reversal studies. | EIDINOFF, ML., et al. 1959. Cancer Res. 19: 638-42. PMID: 13671426
- Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats. | Gavelli, A., et al. 2004. Int J Mol Med. 14: 323-5. PMID: 15254786
- In Vivo Susceptibility of Cryptococcus neoformans to Hamycin, Amphotericin B, and 5-Fluorocytosine. | Shadomy, S., et al. 1970. Infect Immun. 1: 128-34. PMID: 16557685
- 5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy. | Puffer, B., et al. 2009. Nucleic Acids Res. 37: 7728-40. PMID: 19843610
- Chemotherapeutic activity of 5-fluorocytosine against a lethal Candida albicans infection in mice. | Pittillo, RF. and Ray, BJ. 1969. Appl Microbiol. 17: 773-4. PMID: 5785966
- In vitro studies with 5-fluorocytosine. | Shadomy, S. 1969. Appl Microbiol. 17: 871-7. PMID: 5797940
- Incorporation and excision of 5-fluorouracil from deoxyribonucleic acid in Escherichia coli. | Warner, HR. and Rockstroh, PA. 1980. J Bacteriol. 141: 680-6. PMID: 6154037
- Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole. | Perfect, JR. and Durack, DT. 1982. J Infect Dis. 146: 429-35. PMID: 6286799
- Anti-human immunodeficiency virus and anti-hepatitis-B virus activities and toxicities of the enantiomers of 2'-deoxy-3'-oxa-4'-thiocytidine and their 5-fluoro analogues in vitro. | Mansour, TS., et al. 1995. J Med Chem. 38: 1-4. PMID: 7837220
- [Antimycotic activity in vitro and in vivo of 5-fluorocytosine on pathogenic strains of Candida albicans and Cryptococcus neoformans]. | Costa, AL., et al. 1976. G Batteriol Virol Immunol. 69: 244-9. PMID: 800772
- Gas chromatographic determination of 5-fluorocytosine: a modified extraction method. | Wee, SH. and Anhalt, JP. 1977. Antimicrob Agents Chemother. 11: 914-5. PMID: 879744
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Fluoro Cytosine, 5 g | sc-217179 | 5 g | $354.00 |