Date published: 2025-12-5

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5-(Chloromethyl)furfural (CAS 1623-88-7)

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Alternate Names:
2-Formyl-5-chloromethylfuran; 5-(Chloromethyl)-2-furaldehyde; 5-(Chloromethyl)-2-furancarboxaldehyde
Application:
5-(Chloromethyl)furfural is a biofuel precursor used to co-process oil crops into biodiesel
CAS Number:
1623-88-7
Molecular Weight:
144.56
Molecular Formula:
C6H5ClO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-(Chloromethyl)furfural is used to probe enzyme behaviors and to understand the relationship between molecular structure and activity. It is a precursor for the fabrication of polymers and resins with potential industrial and technological applications. 5-(Chloromethyl)furfural is employed in the creation of new polymers and nanomaterials. Acts as an inhibitor of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. The assumed result of this inhibition is an elevated level of acetylcholine, leading to heightened neurotransmission.


5-(Chloromethyl)furfural (CAS 1623-88-7) References

  1. Dramatic advancements in the saccharide to 5-(chloromethyl)furfural conversion reaction.  |  Mascal, M. and Nikitin, EB. 2009. ChemSusChem. 2: 859-61. PMID: 19725092
  2. Synthesis of the insecticide prothrin and its analogues from biomass-derived 5-(chloromethyl)furfural.  |  Chang, F., et al. 2014. J Agric Food Chem. 62: 476-80. PMID: 24354505
  3. Comment on Gao, W., et al. 'Efficient one-pot synthesis of 5-chloromethyl-furfural (CMF) from carbohydrates in mild biphasic systems', Molecules 2013, 18, 7675-7685.  |  Mascal, M. 2014. Molecules. 19: 1367-9. PMID: 24451255
  4. Correction: Gao, W., et al. Efficient One-Pot Synthesis of 5-Chloromethyl-furfural (CMF) from Carbohydrates in Mild Biphasic Systems. Molecules 2013, 18, 7675-7685.  |  Gao, W., et al. 2014. Molecules. 19: 1370-4. PMID: 24451256
  5. Chemical-catalytic approaches to the production of furfurals and levulinates from biomass.  |  Mascal, M. and Dutta, S. 2014. Top Curr Chem. 353: 41-83. PMID: 24842621
  6. Novel pathways to 2,5-dimethylfuran via biomass-derived 5-(chloromethyl)furfural.  |  Dutta, S. and Mascal, M. 2014. ChemSusChem. 7: 3028-30. PMID: 25196591
  7. 5-(Chloromethyl)furfural is the New HMF: Functionally Equivalent But More Practical in Terms of its Production From Biomass.  |  Mascal, M. 2015. ChemSusChem. 8: 3391-5. PMID: 26373463
  8. Hydrochloric acid-catalyzed coproduction of furfural and 5-(chloromethyl)furfural assisted by a phase transfer catalyst.  |  Bhat, NS., et al. 2020. Carbohydr Res. 496: 108105. PMID: 32777538
  9. Green Process for 5-(Chloromethyl)furfural Production from Biomass in Three-Constituent Deep Eutectic Solvent.  |  Chen, B., et al. 2021. ChemSusChem. 14: 847-851. PMID: 33347742
  10. 5-(Chloromethyl)Furfural as a Potential Source for Continuous Hydrogenation of 5-(Hydroxymethyl)Furfural to 2,5-Bis(Hydroxymethyl)Furan.  |  Park, D., et al. 2022. Chempluschem. 87: e202200166. PMID: 35790089
  11. 5-(Chloromethyl)Furfural as a Potential Source for Continuous Hydrogenation of 5-(Hydroxymethyl)Furfural to 2,5-Bis(Hydroxymethyl)Furan.  |  Park, D., et al. 2022. Chempluschem. 87: e202200272. PMID: 36000798
  12. Electrochemical Incorporation of Electrophiles into the Biomass-Derived Platform Molecule 5-(Chloromethyl)furfural.  |  Ling, H., et al. 2023. ChemSusChem. 16: e202201787. PMID: 36525531
  13. Bifunctional NHC-Catalyzed Remote Enantioselective Mannich-type Reaction of 5-(Chloromethyl)furfural via Trienolate Intermediates.  |  Gao, YY., et al. 2023. Angew Chem Int Ed Engl. e202301126. PMID: 36961328

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-(Chloromethyl)furfural, 250 mg

sc-397335
250 mg
$400.00