Molecular structure of 5-Carboxy-8-hydroxyquinoline
5-Carboxy-8-hydroxyquinoline (CAS 5852-78-8)
Alternate Names:
IOX 1; 8-Hydroxy-5-quinolinecarboxylic acid
Application:
5-Carboxy-8-hydroxyquinoline is a histone demethylase JMJD inhibitor
CAS Number:
5852-78-8
Molecular Weight:
189.17
Molecular Formula:
C10H7NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Carboxy-8-hydroxyquinoline is a histone demethylase JMJD inhibitor. 5-Carboxy-8-hydroxyquinoline is cell permeable and inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. It has also shown potential as a plant growth regulator.
5-Carboxy-8-hydroxyquinoline (CAS 5852-78-8) References
- Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. | Rotili, D., et al. 2014. J Med Chem. 57: 42-55. PMID: 24325601
- A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. | Schiller, R., et al. 2014. ChemMedChem. 9: 566-71. PMID: 24504543
- Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline. | Feng, T., et al. 2015. Eur J Med Chem. 105: 145-55. PMID: 26491978
- 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. | Hopkinson, RJ., et al. 2013. Chem Sci. 4: 3110-3117. PMID: 26682036
- JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma. | Macedo-Silva, C., et al. 2020. Cell Death Dis. 11: 1068. PMID: 33318475
- Investigating surface binding effects: antibacterial efficacy of bound 8-hydroxyquinoline against Staphylococcus aureus and Escherichia coli. | Richards, MN., et al. 2021. J Appl Microbiol. 131: 2212-2222. PMID: 33864329
- Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy. | Liu, J., et al. 2021. Nat Commun. 12: 2425. PMID: 33893275
- Developing Metal-Binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds. | Seo, H., et al. 2022. Inorg Chem. 61: 7631-7641. PMID: 35507007
- IOX1 Fails to Reduce α-Globin and Mediates γ-Globin Silencing in Adult β0-Thalassemia/Hemoglobin E Erythroid Progenitor Cells. | Khamphikham, P., et al. 2022. Exp Hematol. 112-113: 9-14.e7. PMID: 35839944
- 8-Hydroxyquinoline-modified ruthenium(II) polypyridyl complexes for JMJD inhibition and photodynamic antitumor therapy. | Ma, X., et al. 2022. Dalton Trans. 51: 13902-13909. PMID: 36040403
- A Three-in-One Nanoscale Coordination Polymer for Potent Chemo-Immunotherapy. | Liu, J., et al. 2023. Small Methods. 7: e2201437. PMID: 36638256
- IOX-1 suppresses metastasis of osteosarcoma by upregulating histone H3 lysine trimethylation. | Chang, SL., et al. 2023. Biochem Pharmacol. 210: 115472. PMID: 36863615
- 8-Hydroxyquinoline: A privileged structure with a broad-ranging pharmacological potential | Xu, H., Chen, W., Zhan, P., & Liu, X. 2015. MedChemComm. 6(1): 61-74.
Inhibitor of:
JMJD3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Carboxy-8-hydroxyquinoline, 5 mg | sc-397023 | 5 mg | $86.00 |