Molecular structure of 5,5′-Dihydroxylysinonorleucine, CAS Number: 32619-23-1
5,5′-Dihydroxylysinonorleucine (CAS 32619-23-1)
See product citations (6)
Alternate Names:
(5S,5′S)-Dihydroxy Lysinonorleucine; N6-[(2S,5S)-5-amino-5-carboxy-2-hydroxypentyl]-5-hydroxy-L-lysine
Application:
5,5′-Dihydroxylysinonorleucine is a collagen reducible crosslink agent
CAS Number:
32619-23-1
Molecular Weight:
307.34
Molecular Formula:
C12H25N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5,5′-Dihydroxylysinonorleucine (DHLNL) is a collagen reducible crosslink agent. It works by inhibiting the activity of various enzymes, including cyclooxygenase-2 (COX-2) and phosphodiesterase-4 (PDE4), and modulates the activity of various signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway and the nuclear factor-kappa B (NF-κB) pathway. 5,5′-Dihydroxylysinonorleucine may act to exhibit anti-inflammatory, anti-cancer, and neuroprotective properties.
5,5′-Dihydroxylysinonorleucine (CAS 32619-23-1) References
- Synthesis of reduced collagen crosslinks. | van den Nieuwendijk, AM., et al. 1999. Bioorg Med Chem Lett. 9: 1673-6. PMID: 10397498
- In vitro inhibition of collagen cross links by catechol analogs. | Murray, JC., et al. 1977. J Invest Dermatol. 68: 146-50. PMID: 14215
- The identity of a cyanogen bromide fragment of bovine dentin collagen containing the site of an intermolecular cross-link. | Scott, PG., et al. 1976. Biochemistry. 15: 3191-8. PMID: 182206
- Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process. | Sell, DR. and Monnier, VM. 1989. J Biol Chem. 264: 21597-602. PMID: 2513322
- Effect of experimental chronic renal insufficiency on bone mineral and collagen maturation. | Russell, JE. and Avioli, LV. 1972. J Clin Invest. 51: 3072-9. PMID: 4640950
- Chemistry of collagen cross-linking: biochemical changes in collagen during the partial mineralization of turkey leg tendon. | Knott, L., et al. 1997. Biochem J. 322 (Pt 2): 535-42. PMID: 9065774
- Amyloid A: amphipathic helixes and lipid binding. | Segrest, JP., et al. 1976. Biochemistry. 15: 3187-91. PMID: 952852
- The Collagen Of Heart Valve | David Collins, et al. 1977. Biochimica et Biophysica Acta (BBA) - Protein Structure. 495: 129-139.
- Reduced Collagen Cross Links: The First Synthesis Of All The Possible (2s,2′S)-Stereoisomers Of 5-Hydroxylysinonorleucine And Of 5,5′-Dihydroxylysinonorleucine In Enantiomerically Pure Form | Riccardo Cribiù, et al. 2005. Tetrahedron: Asymmetry. 16: 3059-3069.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5,5′-Dihydroxylysinonorleucine, 500 µg | sc-207059 | 500 µg | $784.00 | |||
5,5′-Dihydroxylysinonorleucine, 1 mg | sc-207059B | 1 mg | $940.00 | |||
5,5′-Dihydroxylysinonorleucine, 2 mg | sc-207059C | 2 mg | $1200.00 | |||
5,5′-Dihydroxylysinonorleucine, 5 mg | sc-207059D | 5 mg | $2200.00 | |||
5,5′-Dihydroxylysinonorleucine, 10 mg | sc-207059E | 10 mg | $3500.00 |