Date published: 2026-5-1

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4-(Trifluoromethoxy)chlorobenzene (CAS 461-81-4)

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CAS Number:
461-81-4
Molecular Weight:
196.55
Molecular Formula:
C7H4ClF3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-(Trifluoromethoxy)chlorobenzene holds significant importance as an organic compound widely employed in both industrial and scientific realms. It exhibits the characteristics of a colorless, volatile liquid accompanied by a sweet yet pungent odor. The notable reactivity of 4-(Trifluoromethoxy)chlorobenzene is attributed to the presence of the trifluoromethoxy group, which imparts its distinctive properties. The versatility of 4-(Trifluoromethoxy)chlorobenzene extends to numerous scientific research applications, where it serves as a reagent in organic synthesis and as a foundational component for the production of other organic compounds. The trifluoromethoxy group within 4-(Trifluoromethoxy)chlorobenzene endows it with high reactivity. Functioning as a nucleophile, this group initiates attacks on electrophilic centers within other molecules, thereby facilitating the formation of covalent bonds. This reactivity proves instrumental in organic synthesis, enabling the creation of a wide array of compounds, including polymers, dyes, and other materials.


4-(Trifluoromethoxy)chlorobenzene (CAS 461-81-4) References

  1. General Method for the Amination of Aryl Halides with Primary and Secondary Alkyl Amines via Nickel Photocatalysis.  |  Song, G., et al. 2022. J Org Chem. 87: 10285-10297. PMID: 35877165

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-(Trifluoromethoxy)chlorobenzene, 5 g

sc-261522
5 g
$68.00

4-(Trifluoromethoxy)chlorobenzene, 25 g

sc-261522A
25 g
$222.00