4-oxo 2-Nonenal-d3 (CAS 1313400-91-7)
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4-oxo 2-Nonenal-d3 (4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is used for an internal standard for the quantification of 4-ONE by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid(1,2). It exhibits various biological activities such as cytotoxicity, genotoxicity, growth inhibiting activity, chemotactic activity and has been widely used as a marker of lipid peroxidation(1,2,3). 4-ONE is a recently identified product of lipid peroxidation(4,5,6). It actively modifies histidine and lysine residues on proteins and causes protein cross-linking(7,8). 4-ONE also modifies 2′-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis(1).
4-oxo 2-Nonenal-d3 (CAS 1313400-91-7) References
1 Pryor, W.A., Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990). 2 Esterbauer, H., Schaur, R.J., Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991). 3 Sodum, R.S., Chung, F. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res 48 320-323 (1988). 4 Rindgen, D., Nakajima, M., Wehrli, S., et al. Covalent modifications to 2'-deoxyguanosine by 4-oxo-nonenal, a novel product of lipid peroxidation. Chem Res Toxicol 12 1195-1204 (1999). 5 Lee, S.H., Blair, I.A. Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol 13 698-702 (2000). 6 Spiteller, P., Kern, W., Reiner, J., et al. Aldehydic lipid peroxidation products derived from linoleic acid. Biochim Biophys Acta 1531 188-208 (2001). 7 Liu, Z., Minkler, P.E., Sayre, L.M. Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chem Res Toxicol 16 901-911 (2003). 8 Zhang, W., Liu, J., Xu, G., et al. Model studies on protein side chain modification by 4-oxo-2-nonenal. Chem Res Toxicol 16 512-523 (2003).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-oxo 2-Nonenal-d3, 50 µg | sc-220992 | 50 µg | $112.00 | |||
4-oxo 2-Nonenal-d3, 100 µg | sc-220992A | 100 µg | $214.00 |