Date published: 2025-9-26

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4-Ethoxyaniline (CAS 156-43-4)

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Alternate Names:
p-Phenetidine
CAS Number:
156-43-4
Purity:
≥98%
Molecular Weight:
137.18
Molecular Formula:
C8H11NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Ethoxyaniline functions as a precursor in the synthesis of various organic compounds. It acts as a building block in the production of dyes and agrochemicals. 4-Ethoxyaniline is utilized for its role as a starting material in the creation of complex molecules with specific properties. Its mechanism of action involves participating in various chemical reactions, such as diazotization, acylation, and nitration, to introduce specific functional groups into the target molecules. 4-Ethoxyaniline can undergo further derivatization to yield a wide range of derivatives with diverse applications in the field of organic synthesis.


4-Ethoxyaniline (CAS 156-43-4) References

  1. The degradation of paracetamol (4-hydroxyacetanilide) and other substituted acetanilides by a Penicillium species.  |  Hart, A. and Orr, DL. 1975. Antonie Van Leeuwenhoek. 41: 239-47. PMID: 1082294
  2. Inhalation toxicity of 4-ethoxyaniline (p-phenetidine): critical analysis of results of subacute inhalation exposure studies in rats.  |  Pauluhn, J. and Mohr, U. 2001. Inhal Toxicol. 13: 993-1013. PMID: 11696870
  3. Cellular effects of some metabolic oxidation products pertinent to 4-ethoxyaniline.  |  Lindqvist, T., et al. 1991. Pharmacol Toxicol. 69: 117-21. PMID: 1775431
  4. On the chemistry of the reaction between N-acetylcysteine and 4-[(4-ethoxyphenyl)imino]-2,5-cyclohexadien-1-one, a 4-ethoxyaniline metabolite formed during peroxidase reactions.  |  Lindqvist, T., et al. 1991. Chem Res Toxicol. 4: 489-96. PMID: 1912338
  5. Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.  |  Fischer, V., et al. 1986. Chem Biol Interact. 60: 115-27. PMID: 3024853
  6. Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties.  |  Bilginer, S., et al. 2020. J Enzyme Inhib Med Chem. 35: 325-329. PMID: 31813300
  7. Development of NIR-II Photoacoustic Probes Tailored for Deep-Tissue Sensing of Nitric Oxide.  |  Lucero, MY., et al. 2021. J Am Chem Soc. 143: 7196-7202. PMID: 33905646
  8. Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media.  |  Nie, HJ., et al. 2019. RSC Adv. 9: 13249-13253. PMID: 35520758
  9. One-Step, Low-Cost, Operator-Friendly, and Scalable Procedure to Synthetize Highly Pure N-(4-ethoxyphenyl)-retinamide in Quantitative Yield without Purification Work-Up.  |  Alfei, S. and Zuccari, G. 2022. Molecules. 27: PMID: 35684568
  10. Accelerated and Concerted Aza-Michael Addition and SuFEx Reaction in Microdroplets in Unitary and High-Throughput Formats.  |  Ghosh, J., et al. 2022. Angew Chem Int Ed Engl. 61: e202214090. PMID: 36253886
  11. Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of N-Aryl Isoindolinones.  |  Morlacci, V., et al. 2022. Molecules. 27: PMID: 36500288
  12. Sulfhemoglobinemia and methemoglobinemia following acetaminophen overdose.  |  Seltzer, JA., et al. 2022. Toxicol Rep. 9: 1725-1727. PMID: 36561956
  13. Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen.  |  Nedeljković, N., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37242450

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Ethoxyaniline, 100 g

sc-226626
100 g
$61.00